TET-TDG Active DNA Demethylation at CpG and Non-CpG Sites.

DeNizio, Jamie E; Dow, Blaine J; Serrano, Juan C; Ghanty, Uday; Drohat, Alexander C; Kohli, Rahul M

DeNizio, Jamie E; Dow, Blaine J; Serrano, Juan C; Ghanty, Uday; Drohat, Alexander C; Kohli, Rahul M.

Afiliación

DeNizio JE; Graduate Group in Biochemistry and Molecular Biophysics, Perelman School of Medicine, Philadelphia, PA 19147, USA; Department of Medicine, Department of Biochemistry & Biophysics, Perelman School of Medicine, Philadelphia, PA 19147, USA.
Dow BJ; Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Serrano JC; Graduate Group in Biochemistry and Molecular Biophysics, Perelman School of Medicine, Philadelphia, PA 19147, USA; Department of Medicine, Department of Biochemistry & Biophysics, Perelman School of Medicine, Philadelphia, PA 19147, USA.
Ghanty U; Department of Medicine, Department of Biochemistry & Biophysics, Perelman School of Medicine, Philadelphia, PA 19147, USA.
Drohat AC; Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201, USA. Electronic address: adrohat@som.umaryland.edu.
Kohli RM; Department of Medicine, Department of Biochemistry & Biophysics, Perelman School of Medicine, Philadelphia, PA 19147, USA. Electronic address: rkohli@pennmedicine.upenn.edu.

J Mol Biol ; 433(8): 166877, 2021 04 16.

Article en En | MEDLINE | ID: mdl-33561435

Asunto(s)

Islas de CpG; Desmetilación del ADN; Timina ADN Glicosilasa/química; Timina ADN Glicosilasa/metabolismo; 5-Metilcitosina/análogos & derivados; Citosina/análogos & derivados; Reparación del ADN; Proteínas de Unión al ADN/química; Proteínas de Unión al ADN/metabolismo; Dioxigenasas; Epigénesis Genética; Humanos; Oxidación-Reducción; Proteínas Proto-Oncogénicas/química; Proteínas Proto-Oncogénicas/metabolismo; Timina ADN Glicosilasa/genética

Palabras clave

5-hydroxymethylcytosine; 5-methylcytosine; DNA methylation; base excision repair; cytosine-guanine dinucleotides

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Islas de CpG / Timina ADN Glicosilasa / Desmetilación del ADN Límite: Humans Idioma: En Revista: J Mol Biol Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos

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