A Tertiary Academic Medical Center Blood Bank's Experience With Four-Factor Prothrombin Complex Concentrate.
Am J Clin Pathol
; 156(2): 246-252, 2021 07 06.
Article
en En
| MEDLINE
| ID: mdl-33609094
ABSTRACT
OBJECTIVES:
The role of transfusion medicine consultative services in prospectively auditing (PA) orders for four-factor prothrombin complex concentrate (4F-PCC) was evaluated at an academic medical center.METHODS:
Data from 4 years of 4F-PCC orders were obtained from the laboratory information system, and electronic health records of patients receiving concentrate were reviewed.RESULTS:
4F-PCC was ordered for 427 patients with warfarin-, apixaban-, or rivaroxaban-associated hemorrhage. Turnaround time (TAT) to prepare 4F-PCC was longer when PA-recommended dose adjustments were needed (85 vs 66 minutes, Pâ =â .03). There was no difference in TAT between patients who died and those who were ultimately discharged (60 vs 70, Pâ =â .22). TAT was shortest for orders originating in the emergency department (ED) compared with other locations (64 vs 85, Pâ <â .001), and ED TAT was not associated with patient outcomes in ED patients. PA and dose adjustments reduced amounts of concentrate issued by 27 IU per dose (Pâ =â .01). Median international normalized ratio less than 1.3 after 4F-PCC transfusion was achieved for all anticoagulants after dose adjustments. PA did not affect order cancellation or product wastage rates.CONCLUSIONS:
PA can ensure 4F-PCC is dosed appropriately without affecting patient outcomes.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Contexto en salud:
1_ASSA2030
Problema de salud:
1_sistemas_informacao_saude
Asunto principal:
Patología Clínica
/
Bancos de Sangre
/
Factores de Coagulación Sanguínea
/
Almacenamiento de Sangre
/
Hemorragia
Límite:
Humans
Idioma:
En
Revista:
Am J Clin Pathol
Año:
2021
Tipo del documento:
Article
País de afiliación:
Estados Unidos