Sequential and co-occurring DNA damage response genetic mutations impact survival in stage III colorectal cancer patients receiving adjuvant oxaliplatin-based chemotherapy.

Lin, Peng-Chan; Yeh, Yu-Min; Chan, Ren-Hao; Lin, Bo-Wen; Chen, Po-Chuan; Pan, Chien-Chang; Shen, Meng-Ru

Lin, Peng-Chan; Yeh, Yu-Min; Chan, Ren-Hao; Lin, Bo-Wen; Chen, Po-Chuan; Pan, Chien-Chang; Shen, Meng-Ru.

Afiliación

Lin PC; Department of Oncology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Yeh YM; Department of Genomic Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Chan RH; Department of Computer Science and Information Engineering, College of Electrical Engineering and Computer Science, National Cheng Kung University, Tainan, Taiwan.
Lin BW; Department of Oncology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Chen PC; Department of Surgery, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Pan CC; Department of Surgery, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Shen MR; Department of Surgery, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.

BMC Cancer ; 21(1): 217, 2021 Mar 02.

Article en En | MEDLINE | ID: mdl-33653301

Asunto(s)

Neoplasias Colorrectales/genética; Daño del ADN; Mutación; Oxaliplatino/administración & dosificación; Proteína de la Poliposis Adenomatosa del Colon/genética; Anciano; Proteína BRCA2/genética; Neoplasias Colorrectales/tratamiento farmacológico; Neoplasias Colorrectales/mortalidad; Neoplasias Colorrectales/patología; Femenino; Humanos; Masculino; Persona de Mediana Edad; Estadificación de Neoplasias; Filogenia; Proteínas Proto-Oncogénicas p21(ras)/genética

Palabras clave

Colorectal cancer; DNA damage response gene; Sequential somatic mutations; Tumor evolution; Tumor heterogeneity

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Daño del ADN / Neoplasias Colorrectales / Oxaliplatino / Mutación Tipo de estudio: Prognostic_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: BMC Cancer Asunto de la revista: NEOPLASIAS Año: 2021 Tipo del documento: Article País de afiliación: Taiwán

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