Downregulation of connexin43 potentiates noradrenaline-induced expression of brain-derived neurotrophic factor in primary cultured cortical astrocytes.

Morioka, Norimitsu; Kondo, Syun; Harada, Nanase; Takimoto, Tomoyo; Tokunaga, Nozomi; Nakamura, Yoki; Hisaoka-Nakashima, Kazue; Nakata, Yoshihiro

Morioka, Norimitsu; Kondo, Syun; Harada, Nanase; Takimoto, Tomoyo; Tokunaga, Nozomi; Nakamura, Yoki; Hisaoka-Nakashima, Kazue; Nakata, Yoshihiro.

Afiliación

Morioka N; Department of Pharmacology, Hiroshima University Graduate School of Biomedical and Health Sciences, Kasumi 1-2-3, Minami-ku, Hiroshima, Japan.
Kondo S; Department of Pharmacology, Hiroshima University Graduate School of Biomedical and Health Sciences, Kasumi 1-2-3, Minami-ku, Hiroshima, Japan.
Harada N; Department of Pharmacology, Hiroshima University Graduate School of Biomedical and Health Sciences, Kasumi 1-2-3, Minami-ku, Hiroshima, Japan.
Takimoto T; Department of Pharmacology, Hiroshima University Graduate School of Biomedical and Health Sciences, Kasumi 1-2-3, Minami-ku, Hiroshima, Japan.
Tokunaga N; Department of Pharmacology, Hiroshima University Graduate School of Biomedical and Health Sciences, Kasumi 1-2-3, Minami-ku, Hiroshima, Japan.
Nakamura Y; Department of Pharmacology, Hiroshima University Graduate School of Biomedical and Health Sciences, Kasumi 1-2-3, Minami-ku, Hiroshima, Japan.
Hisaoka-Nakashima K; Department of Pharmacology, Hiroshima University Graduate School of Biomedical and Health Sciences, Kasumi 1-2-3, Minami-ku, Hiroshima, Japan.
Nakata Y; Department of Pharmacology, Hiroshima University Graduate School of Biomedical and Health Sciences, Kasumi 1-2-3, Minami-ku, Hiroshima, Japan.

J Cell Physiol ; 236(10): 6777-6792, 2021 10.

Article en En | MEDLINE | ID: mdl-33665818

Asunto(s)

Astrocitos/efectos de los fármacos; Factor Neurotrófico Derivado del Encéfalo/metabolismo; Corteza Cerebral/efectos de los fármacos; Conexina 43/metabolismo; Norepinefrina/farmacología; Animales; Animales Recién Nacidos; Astrocitos/metabolismo; Factor Neurotrófico Derivado del Encéfalo/genética; Células Cultivadas; Corteza Cerebral/citología; Corteza Cerebral/metabolismo; Conexina 43/genética; Regulación hacia Abajo; Quinasas MAP Reguladas por Señal Extracelular/metabolismo; Femenino; Técnicas de Silenciamiento del Gen; Masculino; Cultivo Primario de Células; Interferencia de ARN; Ratas Wistar; Receptores Adrenérgicos alfa 1/efectos de los fármacos; Receptores Adrenérgicos alfa 1/metabolismo; Receptores Adrenérgicos beta/efectos de los fármacos; Receptores Adrenérgicos beta/metabolismo; Transducción de Señal; Familia-src Quinasas/metabolismo

Palabras clave

Src; adrenergic receptors; astrocytes; brain-derived neurotrophic factor; connexin43; extracellular signal-regulated kinase

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Norepinefrina / Corteza Cerebral / Astrocitos / Conexina 43 / Factor Neurotrófico Derivado del Encéfalo Límite: Animals Idioma: En Revista: J Cell Physiol Año: 2021 Tipo del documento: Article País de afiliación: Japón

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