Unique structural features of flaviviruses' capsid proteins: new insights on structure-function relationship.
Curr Opin Virol
; 47: 106-112, 2021 04.
Article
en En
| MEDLINE
| ID: mdl-33721656
ABSTRACT
The Flaviviridae family comprises important human pathogens, including Dengue, Zika, West Nile, Yellow Fever and Japanese Encephalitis viruses. The viral genome, a positive-sense single-stranded RNA, is packaged by a single protein, the capsid protein, which is a small and highly basic protein that form intertwined homodimers in solution. Atomic-resolution structures of four flaviviruses capsid proteins were solved either in solution by nuclear magnetic resonance spectroscopy, or after protein crystallization by X-ray diffraction. Analyses of these structures revealed very particular properties, namely (i) the predominance of quaternary contacts maintaining the structure; (ii) a highly electropositive surface throughout the protein; and (iii) a flexible helix (α1). The goal of this review is to discuss the role of these features in protein structure-function relationship.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Contexto en salud:
3_ND
Problema de salud:
3_dengue
Asunto principal:
Proteínas de la Cápside
/
Flavivirus
Límite:
Humans
Idioma:
En
Revista:
Curr Opin Virol
Año:
2021
Tipo del documento:
Article
País de afiliación:
Brasil