Signal transduction in primary cilia - analyzing and manipulating GPCR and second messenger signaling.
Pharmacol Ther
; 224: 107836, 2021 08.
Article
en En
| MEDLINE
| ID: mdl-33744260
ABSTRACT
The primary cilium projects from the surface of most vertebrate cells, where it senses extracellular signals to regulate diverse cellular processes during tissue development and homeostasis. Dysfunction of primary cilia underlies the pathogenesis of severe diseases, commonly referred to as ciliopathies. Primary cilia contain a unique protein repertoire that is distinct from the cell body and the plasma membrane, enabling the spatially controlled transduction of extracellular cues. G-protein coupled receptors (GPCRs) are key in sensing environmental stimuli that are transmitted via second messenger signaling into a cellular response. Here, we will give an overview of the role of GPCR signaling in primary cilia, and how ciliary GPCR signaling can be targeted by pharmacology, chemogenetics, and optogenetics.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Transducción de Señal
/
Cilios
Límite:
Humans
Idioma:
En
Revista:
Pharmacol Ther
Año:
2021
Tipo del documento:
Article