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Evaluating the effect of spaceflight on the host-pathogen interaction between human intestinal epithelial cells and Salmonella Typhimurium.
Barrila, Jennifer; Sarker, Shameema F; Hansmeier, Nicole; Yang, Shanshan; Buss, Kristina; Briones, Natalia; Park, Jin; Davis, Richard R; Forsyth, Rebecca J; Ott, C Mark; Sato, Kevin; Kosnik, Cristine; Yang, Anthony; Shimoda, Cheryl; Rayl, Nicole; Ly, Diana; Landenberger, Aaron; Wilson, Stephanie D; Yamazaki, Naoko; Steel, Jason; Montano, Camila; Halden, Rolf U; Cannon, Tom; Castro-Wallace, Sarah L; Nickerson, Cheryl A.
Afiliación
  • Barrila J; Biodesign Center for Fundamental and Applied Microbiomics, Arizona State University, Tempe, AZ, USA.
  • Sarker SF; Biodesign Center for Infectious Diseases and Vaccinology, Arizona State University, Tempe, AZ, USA.
  • Hansmeier N; Biodesign Center for Infectious Diseases and Vaccinology, Arizona State University, Tempe, AZ, USA.
  • Yang S; Swette Center for Environmental Biotechnology, The Biodesign Institute, Arizona State University, Tempe, AZ, USA.
  • Buss K; Luther College at University of Regina, Department of Biology, Regina, Saskatchewan, Canada.
  • Briones N; Bioinformatics Core Facility, Bioscience, Knowledge Enterprise, Arizona State University, Tempe, AZ, USA.
  • Park J; Bioinformatics Core Facility, Bioscience, Knowledge Enterprise, Arizona State University, Tempe, AZ, USA.
  • Davis RR; Bioinformatics Core Facility, Bioscience, Knowledge Enterprise, Arizona State University, Tempe, AZ, USA.
  • Forsyth RJ; Integrated Cancer Genomics Division, The Translational Genomics Research Institute, Phoenix, AZ, USA.
  • Ott CM; Bioinformatics Core Facility, Bioscience, Knowledge Enterprise, Arizona State University, Tempe, AZ, USA.
  • Sato K; Biodesign Center for Fundamental and Applied Microbiomics, Arizona State University, Tempe, AZ, USA.
  • Kosnik C; Biodesign Center for Infectious Diseases and Vaccinology, Arizona State University, Tempe, AZ, USA.
  • Yang A; Biodesign Center for Infectious Diseases and Vaccinology, Arizona State University, Tempe, AZ, USA.
  • Shimoda C; Biomedical Research and Environmental Sciences Division, NASA Johnson Space Center, Houston, TX, USA.
  • Rayl N; NASA Ames Research Center, Mountain View, CA, USA.
  • Ly D; Tissue Genesis, Inc, Honolulu, HI, USA.
  • Landenberger A; Tissue Genesis, Inc, Honolulu, HI, USA.
  • Wilson SD; Tissue Genesis, Inc, Honolulu, HI, USA.
  • Yamazaki N; NASA Ames Research Center, Mountain View, CA, USA.
  • Steel J; NASA Headquarters, Washington, D.C., USA.
  • Montano C; NASA Ames Research Center, Mountain View, CA, USA.
  • Halden RU; DoD Space Test Program, Houston, TX, USA.
  • Cannon T; Astronaut Office, NASA Johnson Space Center, Houston, TX, USA.
  • Castro-Wallace SL; Space Biomedical Research Office, Human Space Technology and Astronauts Department, Japan Aerospace Exploration Agency (JAXA), Tokyo, Japan.
  • Nickerson CA; Bioinformatics Core Facility, Bioscience, Knowledge Enterprise, Arizona State University, Tempe, AZ, USA.
NPJ Microgravity ; 7(1): 9, 2021 Mar 09.
Article en En | MEDLINE | ID: mdl-33750813
Spaceflight uniquely alters the physiology of both human cells and microbial pathogens, stimulating cellular and molecular changes directly relevant to infectious disease. However, the influence of this environment on host-pathogen interactions remains poorly understood. Here we report our results from the STL-IMMUNE study flown aboard Space Shuttle mission STS-131, which investigated multi-omic responses (transcriptomic, proteomic) of human intestinal epithelial cells to infection with Salmonella Typhimurium when both host and pathogen were simultaneously exposed to spaceflight. To our knowledge, this was the first in-flight infection and dual RNA-seq analysis using human cells.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: NPJ Microgravity Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: NPJ Microgravity Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos