ICOSL in host defense at epithelial barriers: lessons from ICOSLG deficiency.
Curr Opin Immunol
; 72: 21-26, 2021 10.
Article
en En
| MEDLINE
| ID: mdl-33756276
ABSTRACT
Autosomal recessive mutations in Inducible T Cell Costimulator Ligand (ICOSLG) result in a combined immunodeficiency syndrome of humans, saliently marked by recurrent respiratory tract infections and significant disease with DNA-based viruses at epithelial barriers, including human papillomavirus (HPV). These features are also seen in persons with loss of function of the complementary gene, ICOS. The infection phenotypes associated with these natural experiments disclose a critical role of the corresponding proteins, ICOSL and ICOS, in human immunity at mucocutaneous barriers. Here, we review the syndromes of ICOSL and ICOS deficiency and explore the mechanisms by which the ICOSLICOS axis mediates epithelial host defenses.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Epitelio
/
Interacciones Huésped-Patógeno
/
Resistencia a la Enfermedad
/
Ligando Coestimulador de Linfocitos T Inducibles
Tipo de estudio:
Etiology_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Curr Opin Immunol
Asunto de la revista:
ALERGIA E IMUNOLOGIA
Año:
2021
Tipo del documento:
Article
País de afiliación:
Canadá