A Baeyer-Villiger monooxygenase from Cupriavidus basilensis catalyzes asymmetric synthesis of (R)-lansoprazole and other pharmaco-sulfoxides.

Liu, Feng; Shou, Chao; Geng, Qiang; Zhao, Chen; Xu, Jianhe; Yu, Huilei

Liu, Feng; Shou, Chao; Geng, Qiang; Zhao, Chen; Xu, Jianhe; Yu, Huilei.

Afiliación

Liu F; State Key Laboratory of Bioreactor Engineering, Shanghai Collaborative Innovation Center for Biomanufacturing and School of Biotechnology, East China University of Science and Technology, 130 Meilong Road, Shanghai, 200237, China.
Shou C; State Key Laboratory of Bioreactor Engineering, Shanghai Collaborative Innovation Center for Biomanufacturing and School of Biotechnology, East China University of Science and Technology, 130 Meilong Road, Shanghai, 200237, China.
Geng Q; State Key Laboratory of Bioreactor Engineering, Shanghai Collaborative Innovation Center for Biomanufacturing and School of Biotechnology, East China University of Science and Technology, 130 Meilong Road, Shanghai, 200237, China.
Zhao C; State Key Laboratory of Bioreactor Engineering, Shanghai Collaborative Innovation Center for Biomanufacturing and School of Biotechnology, East China University of Science and Technology, 130 Meilong Road, Shanghai, 200237, China.
Xu J; State Key Laboratory of Bioreactor Engineering, Shanghai Collaborative Innovation Center for Biomanufacturing and School of Biotechnology, East China University of Science and Technology, 130 Meilong Road, Shanghai, 200237, China. jianhexu@ecust.edu.cn.
Yu H; State Key Laboratory of Bioreactor Engineering, Shanghai Collaborative Innovation Center for Biomanufacturing and School of Biotechnology, East China University of Science and Technology, 130 Meilong Road, Shanghai, 200237, China. huileiyu@ecust.edu.cn.

Appl Microbiol Biotechnol ; 105(8): 3169-3180, 2021 Apr.

Article en En | MEDLINE | ID: mdl-33779786

Asunto(s)

Oxigenasas de Función Mixta; Sulfóxidos; Bradyrhizobium; Cupriavidus; Dexlansoprazol; Oxigenasas de Función Mixta/metabolismo; Oxidación-Reducción; Filogenia; Especificidad por Sustrato

Palabras clave

(R)-lansoprazole; Baeyer-Villiger monooxygenase; asymmetric sulfoxidation; proton pump inhibitor

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sulfóxidos / Oxigenasas de Función Mixta Idioma: En Revista: Appl Microbiol Biotechnol Año: 2021 Tipo del documento: Article País de afiliación: China

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