[A preliminary study on the biomarkers of local inflammation in allergic rhinitis].
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
; 35(4): 306-311;315, 2021 Apr.
Article
en Zh
| MEDLINE
| ID: mdl-33794626
ABSTRACT
Objective:
This study aimed to explore the biomarkers in nasal secretion that can assist in the diagnosis of allergic rhinitisï¼ARï¼ and can be used to evaluate the therapeutic effect of AR.Methods:
Thirty-three patients with AR and 21 healthy controls were included. The nasal secretion of healthy controls and patients with ARï¼before and after treatmentï¼ were collected. The cytology, the concentrations of cytokinesï¼IL-5, IL-6, IL-8, IL-33, IFN-Î³ï¼ and inflammatory mediatorsï¼ECP, MPOï¼ were detected. Then, we compared the differences of various biomarkers between healthy controls and AR patientsï¼before and after treatment groupï¼. And analyzed the correlation between each biomarkers/biomarkers difference value/the percentage of biomarkers difference value and clinical symptom score/ score difference value / the percentage of score difference value.Results:
Compared with normal controls, the levels of ECP, IL-5, IL-6, IL-8, IL-33 and IFN-γ in nasal secretion of AR patients were significantly higher than those of normal controlsï¼P<0.05ï¼. There was no significant difference in MPO. After treatment, ECP decreased significantlyï¼P<0.01ï¼, inflammatory cell grade and eosinophil percentage are also decreasedï¼P<0.01ï¼. However, MPO, IL-5, IL-6, IL-8, IL-33 and IFN-γ did not change significantly. The difference value of ECP before and after treatment was correlated with the difference value of VAS scoreï¼r=0.348, P=0.047ï¼. The difference value of IL-5 was correlated with the difference value of VAS score and rhinorrhea, the correlation coefficients were 0.406ï¼P=0.019ï¼ and 0.429ï¼P=0.013ï¼, respectively. The difference value of eosinophil percentage in nasal secretion before and after treatment was correlated with nasal congestion, and the correlation coefficient was 0.383. The difference value of eosinophil percentage multiplied by inflammatory cell grade before and after treatment was correlated with VAS scoreï¼r=0.417, P=0.016ï¼ and nasal congestion difference valueï¼r=0.519, P=0.002ï¼. The percentage of difference value of IFN-γ before and after treatment was correlated with the percentage of difference value of VAS score / rhinorrhea / sneeze / total nasal symptom score.Conclusion:
ECP, IL-6, IL-8 and IL-33 in nasal secretion are expected to be objective biomarkers for auxiliary diagnosis of AR. And ECP, IL-5, IFN-γ, eosinophil percentage multiplied by grade is expected to be an objective index to judge the improvement of patients' symptoms after treatment.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Rinitis Alérgica
Tipo de estudio:
Diagnostic_studies
Límite:
Humans
Idioma:
Zh
Revista:
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
Año:
2021
Tipo del documento:
Article