Olfactory perception of food abundance regulates dietary restriction-mediated longevity via a brain-to-gut signal.
Nat Aging
; 1(3): 255-268, 2021 03.
Article
en En
| MEDLINE
| ID: mdl-33796867
ABSTRACT
The role of food nutrients in mediating the positive effect of dietary restriction (DR) on longevity has been extensively characterized, but how non-nutrient food components regulate lifespan is not well understood. Here, we show that food-associated odors shorten the lifespan of C. elegans under DR but not those fed ad libitum, revealing a specific effect of food odors on DR-mediated longevity. Food odors act on a neural circuit comprising the sensory neurons ADF and CEP, and the interneuron RIC. This olfactory circuit signals the gut to suppress DR-mediated longevity via octopamine, the invertebrate homolog of norepinephrine, by regulating the energy sensor AMPK through a Gq-PLCß-CaMKK-dependent mechanism. In mouse primary cells, we find that norepinephrine signaling regulates AMPK through a similar mechanism. Our results identify a brain-gut axis that regulates DR-mediated longevity by relaying olfactory information about food abundance from the brain to the gut.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Proteínas de Caenorhabditis elegans
/
Percepción Olfatoria
Límite:
Animals
Idioma:
En
Revista:
Nat Aging
Año:
2021
Tipo del documento:
Article
País de afiliación:
China