Metallo-ß-Lactamases: Influence of the Active Site Structure on the Mechanisms of Antibiotic Resistance and Inhibition.
Biochemistry (Mosc)
; 86(Suppl 1): S24-S37, 2021 Jan.
Article
en En
| MEDLINE
| ID: mdl-33827398
ABSTRACT
The review focuses on bacterial metallo-ß-lactamases (MßLs) responsible for the inactivation of ß-lactams and associated antibiotic resistance. The diversity of the active site structure in the members of different MßL subclasses explains different mechanisms of antibiotic hydrolysis and should be taken into account when searching for potential MßL inhibitors. The review describes the features of the antibiotic inactivation mechanisms by various MßLs studied by X-ray crystallography, NMR, kinetic measurements, and molecular modeling. The mechanisms of enzyme inhibition for each MßL subclass are discussed.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Beta-Lactamasas
/
Farmacorresistencia Microbiana
/
Dominio Catalítico
Idioma:
En
Revista:
Biochemistry (Mosc)
Año:
2021
Tipo del documento:
Article
País de afiliación:
Rusia