High turnover of types III and VI collagen in progressive idiopathic pulmonary fibrosis.
Respirology
; 26(6): 582-589, 2021 06.
Article
en En
| MEDLINE
| ID: mdl-33834579
ABSTRACT
BACKGROUND AND OBJECTIVE:
Prediction of idiopathic pulmonary fibrosis (IPF) progression is vital for the choice and timing of treatment and patient follow-up. This could potentially be achieved by prognostic blood biomarkers of extracellular matrix (ECM) remodelling.METHODS:
Neoepitope biomarkers of types III and VI collagen turnover (C3M, C6M, PRO-C3 and PRO-C6) were measured in 185 patients with newly diagnosed IPF. Disease severity at baseline and progression over 6 months was assessed by lung function tests and 6-min walk tests. All-cause mortality was assessed over a 3-year follow-up period.RESULTS:
High baseline levels of C3M, C6M, PRO-C3 and PRO-C6 were associated with more advanced disease at the time of diagnosis. Baseline levels of C6M and PRO-C3 were also associated with mortality over 3 years of follow-up (hazard ratio [HR] 2.3, 95% CI 1.3-3.9, p = 0.002 and HR 1.8, 95% CI 1.1-3.0, p = 0.03). Patients with several increased biomarkers at baseline, representing a high ECM remodelling phenotype, had more advanced disease at baseline, higher risk of progression or death at 6 months (OR 1.4, 95% CI 1.1-1.8, p = 0.002) and higher mortality over 3 years of follow-up (HR 2.4, 95% CI 1.3-4.5, p = 0.007).CONCLUSION:
Blood biomarkers of types III and VI collagen turnover, assessed at the time of diagnosis, are associated with several indices of disease severity, short-term progression and long-term mortality. These biomarkers can help to identify patients with a high ECM remodelling phenotype at high risk of disease progression and death.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Contexto en salud:
6_ODS3_enfermedades_notrasmisibles
Problema de salud:
6_other_respiratory_diseases
Asunto principal:
Colágeno
/
Matriz Extracelular
/
Fibrosis Pulmonar Idiopática
Tipo de estudio:
Prognostic_studies
/
Risk_factors_studies
Límite:
Humans
Idioma:
En
Revista:
Respirology
Año:
2021
Tipo del documento:
Article
País de afiliación:
Dinamarca