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Positive allosteric modulation of the mu-opioid receptor produces analgesia with reduced side effects.
Kandasamy, Ram; Hillhouse, Todd M; Livingston, Kathryn E; Kochan, Kelsey E; Meurice, Claire; Eans, Shainnel O; Li, Ming-Hua; White, Andrew D; Roques, Bernard P; McLaughlin, Jay P; Ingram, Susan L; Burford, Neil T; Alt, Andrew; Traynor, John R.
Afiliación
  • Kandasamy R; Edward F. Domino Research Center, Department of Pharmacology, University of Michigan Medical School, Ann Arbor, MI, 48109.
  • Hillhouse TM; Department of Psychology, California State University, East Bay, Hayward, CA, 94542.
  • Livingston KE; Edward F. Domino Research Center, Department of Pharmacology, University of Michigan Medical School, Ann Arbor, MI, 48109.
  • Kochan KE; Department of Psychology, University of Wisconsin-Green Bay, Green Bay, WI, 54311.
  • Meurice C; Edward F. Domino Research Center, Department of Pharmacology, University of Michigan Medical School, Ann Arbor, MI, 48109.
  • Eans SO; Edward F. Domino Research Center, Department of Pharmacology, University of Michigan Medical School, Ann Arbor, MI, 48109.
  • Li MH; Edward F. Domino Research Center, Department of Pharmacology, University of Michigan Medical School, Ann Arbor, MI, 48109.
  • White AD; Department of Pharmacodynamics, University of Florida College of Pharmacy, Gainesville, FL, 32610.
  • Roques BP; Department of Neurological Surgery, Oregon Health and Science University, Portland, OR, 97239.
  • McLaughlin JP; Department of Medicinal Chemistry, College of Pharmacy, University of Michigan, Ann Arbor MI, 48109.
  • Ingram SL; Unité de Technologies Chimiques et Biologiques pour la Santé, Université Paris Descartes, Paris, Cedex 05, France.
  • Burford NT; Department of Pharmacodynamics, University of Florida College of Pharmacy, Gainesville, FL, 32610.
  • Alt A; Department of Neurological Surgery, Oregon Health and Science University, Portland, OR, 97239.
  • Traynor JR; Lead Discovery and Optimization, Bristol-Myers Squibb, Wallingford, CT, 06492.
Proc Natl Acad Sci U S A ; 118(16)2021 04 20.
Article en En | MEDLINE | ID: mdl-33846240
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Dolor / Receptores Opioides mu / Regulación Alostérica Límite: Animals Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2021 Tipo del documento: Article
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Dolor / Receptores Opioides mu / Regulación Alostérica Límite: Animals Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2021 Tipo del documento: Article