Structural Insights into Plasticity and Discovery of Remdesivir Metabolite GS-441524 Binding in SARS-CoV-2 Macrodomain.

Ni, Xiaomin; Schröder, Martin; Olieric, Vincent; Sharpe, May E; Hernandez-Olmos, Victor; Proschak, Ewgenij; Merk, Daniel; Knapp, Stefan; Chaikuad, Apirat

Ni, Xiaomin; Schröder, Martin; Olieric, Vincent; Sharpe, May E; Hernandez-Olmos, Victor; Proschak, Ewgenij; Merk, Daniel; Knapp, Stefan; Chaikuad, Apirat.

Afiliación

Ni X; Structural Genomics Consortium, Buchmann Institute for Molecular Life Sciences, 60438 Frankfurt am Main, Germany.
Schröder M; Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, 60438 Frankfurt am Main, Germany.
Olieric V; Structural Genomics Consortium, Buchmann Institute for Molecular Life Sciences, 60438 Frankfurt am Main, Germany.
Sharpe ME; Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, 60438 Frankfurt am Main, Germany.
Hernandez-Olmos V; Swiss Light Source, Paul Scherrer Institute, 5232 Villigen, Switzerland.
Proschak E; Swiss Light Source, Paul Scherrer Institute, 5232 Villigen, Switzerland.
Merk D; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Theodor-Stern-Kai 7, 60596 Frankfurt, Germany.
Knapp S; Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, 60438 Frankfurt am Main, Germany.
Chaikuad A; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Theodor-Stern-Kai 7, 60596 Frankfurt, Germany.

ACS Med Chem Lett ; 12(4): 603-609, 2021 Apr 08.

Article en En | MEDLINE | ID: mdl-33850605

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: ACS Med Chem Lett Año: 2021 Tipo del documento: Article País de afiliación: Alemania

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