Sacraoxides A-G, Bioactive Cembranoids from Gum Resin of <i>Boswellia sacra</i>.

Zhang, Bingyang; Liu, Di; Ji, Wenyue; Otsuki, Kouharu; Higai, Koji; Zhao, Feng; Li, Wei; Koike, Kazuo; Qiu, Feng

Sacraoxides A-G, Bioactive Cembranoids from Gum Resin of Boswellia sacra.

Zhang, Bingyang; Liu, Di; Ji, Wenyue; Otsuki, Kouharu; Higai, Koji; Zhao, Feng; Li, Wei; Koike, Kazuo; Qiu, Feng.

Afiliación

Zhang B; School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Liu D; School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Ji W; School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Otsuki K; Faculty of Pharmaceutical Sciences, Toho University, Tokyo, Japan.
Higai K; Faculty of Pharmaceutical Sciences, Toho University, Tokyo, Japan.
Zhao F; School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai, China.
Li W; Faculty of Pharmaceutical Sciences, Toho University, Tokyo, Japan.
Koike K; Faculty of Pharmaceutical Sciences, Toho University, Tokyo, Japan.
Qiu F; School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin, China.

Front Chem ; 9: 649287, 2021.

Article en En | MEDLINE | ID: mdl-33869144

ABSTRACT

ABSTRACT

Seven undescribed cembranoids, sacraoxides A-G (1, 3-8) were isolated from the gum resin of Boswellia sacra. Their structures were elucidated by extensive physicochemical and spectroscopic analysis, as well as ECD calculation, modified Mosher's method and X-ray diffraction crystallography. Compounds 6 and 7 exhibited inhibitory activities on nitric oxide (NO) production induced by lipopolysaccharide in RAW264.7 cells with IC50 values of 24.9 ± 1.7 and 36.4 ± 2.9 µM.

Palabras clave

Boswellia sacra; anti-inflammatory; cembranoids; olibanum; phytochemistry; structure elucidation

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Chem Año: 2021 Tipo del documento: Article País de afiliación: China