Your browser doesn't support javascript.
loading
Gut Microbiome in Progressive Multiple Sclerosis.
Cox, Laura M; Maghzi, Amir Hadi; Liu, Shirong; Tankou, Stephanie K; Dhang, Fyonn H; Willocq, Valerie; Song, Anya; Wasén, Caroline; Tauhid, Shahamat; Chu, Renxin; Anderson, Mark C; De Jager, Philip L; Polgar-Turcsanyi, Mariann; Healy, Brian C; Glanz, Bonnie I; Bakshi, Rohit; Chitnis, Tanuja; Weiner, Howard L.
Afiliación
  • Cox LM; Ann Romney Center for Neurologic Diseases, Harvard Medical School, Brigham and Women's Hospital, Boston, MA.
  • Maghzi AH; Ann Romney Center for Neurologic Diseases, Harvard Medical School, Brigham and Women's Hospital, Boston, MA.
  • Liu S; Ann Romney Center for Neurologic Diseases, Harvard Medical School, Brigham and Women's Hospital, Boston, MA.
  • Tankou SK; Mount Sinai Health System, New York, NY.
  • Dhang FH; Ann Romney Center for Neurologic Diseases, Harvard Medical School, Brigham and Women's Hospital, Boston, MA.
  • Willocq V; Department of Neurology, Harvard Medical School, Harvard University Wyss Institute for Biologically Inspired Engineering, Boston, MA.
  • Song A; Ann Romney Center for Neurologic Diseases, Harvard Medical School, Brigham and Women's Hospital, Boston, MA.
  • Wasén C; Ann Romney Center for Neurologic Diseases, Harvard Medical School, Brigham and Women's Hospital, Boston, MA.
  • Tauhid S; Ann Romney Center for Neurologic Diseases, Harvard Medical School, Brigham and Women's Hospital, Boston, MA.
  • Chu R; Ann Romney Center for Neurologic Diseases, Harvard Medical School, Brigham and Women's Hospital, Boston, MA.
  • Anderson MC; Ann Romney Center for Neurologic Diseases, Harvard Medical School, Brigham and Women's Hospital, Boston, MA.
  • De Jager PL; Department of Neurology, Columbia University Medical Center, New York, NY.
  • Polgar-Turcsanyi M; Ann Romney Center for Neurologic Diseases, Harvard Medical School, Brigham and Women's Hospital, Boston, MA.
  • Healy BC; Department of Neurology, Biostatistics Center, Massachusetts General Hospital, Brigham and Women's Hospital, Boston, MA.
  • Glanz BI; Ann Romney Center for Neurologic Diseases, Harvard Medical School, Brigham and Women's Hospital, Boston, MA.
  • Bakshi R; Ann Romney Center for Neurologic Diseases, Harvard Medical School, Brigham and Women's Hospital, Boston, MA.
  • Chitnis T; Ann Romney Center for Neurologic Diseases, Harvard Medical School, Brigham and Women's Hospital, Boston, MA.
  • Weiner HL; Ann Romney Center for Neurologic Diseases, Harvard Medical School, Brigham and Women's Hospital, Boston, MA.
Ann Neurol ; 89(6): 1195-1211, 2021 06.
Article en En | MEDLINE | ID: mdl-33876477
ABSTRACT

OBJECTIVE:

This study was undertaken to investigate the gut microbiome in progressive multiple sclerosis (MS) and how it relates to clinical disease.

METHODS:

We sequenced the microbiota from healthy controls and relapsing-remitting MS (RRMS) and progressive MS patients and correlated the levels of bacteria with clinical features of disease, including Expanded Disability Status Scale (EDSS), quality of life, and brain magnetic resonance imaging lesions/atrophy. We colonized mice with MS-derived Akkermansia and induced experimental autoimmune encephalomyelitis (EAE).

RESULTS:

Microbiota ß-diversity differed between MS patients and controls but did not differ between RRMS and progressive MS or differ based on disease-modifying therapies. Disease status had the greatest effect on the microbiome ß-diversity, followed by body mass index, race, and sex. In both progressive MS and RRMS, we found increased Clostridium bolteae, Ruthenibacterium lactatiformans, and Akkermansia and decreased Blautia wexlerae, Dorea formicigenerans, and Erysipelotrichaceae CCMM. Unique to progressive MS, we found elevated Enterobacteriaceae and Clostridium g24 FCEY and decreased Blautia and Agathobaculum. Several Clostridium species were associated with higher EDSS and fatigue scores. Contrary to the view that elevated Akkermansia in MS has a detrimental role, we found that Akkermansia was linked to lower disability, suggesting a beneficial role. Consistent with this, we found that Akkermansia isolated from MS patients ameliorated EAE, which was linked to a reduction in RORγt+ and IL-17-producing γδ T cells.

INTERPRETATION:

Whereas some microbiota alterations are shared in relapsing and progressive MS, we identified unique bacteria associated with progressive MS and clinical measures of disease. Furthermore, elevated Akkermansia in MS may be a compensatory beneficial response in the MS microbiome. ANN NEUROL 2021;891195-1211.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 3_ND Problema de salud: 3_zoonosis Asunto principal: Esclerosis Múltiple Crónica Progresiva / Esclerosis Múltiple Recurrente-Remitente / Microbioma Gastrointestinal Tipo de estudio: Prognostic_studies Aspecto: Patient_preference Límite: Adult / Animals / Female / Humans / Male / Middle aged Idioma: En Revista: Ann Neurol Año: 2021 Tipo del documento: Article País de afiliación: Marruecos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 3_ND Problema de salud: 3_zoonosis Asunto principal: Esclerosis Múltiple Crónica Progresiva / Esclerosis Múltiple Recurrente-Remitente / Microbioma Gastrointestinal Tipo de estudio: Prognostic_studies Aspecto: Patient_preference Límite: Adult / Animals / Female / Humans / Male / Middle aged Idioma: En Revista: Ann Neurol Año: 2021 Tipo del documento: Article País de afiliación: Marruecos
...