Borneol in cardio-cerebrovascular diseases: Pharmacological actions, mechanisms, and therapeutics.
Pharmacol Res
; 169: 105627, 2021 07.
Article
en En
| MEDLINE
| ID: mdl-33892091
ABSTRACT
With the coming acceleration of global population aging, the incidence rate of cardio-cerebrovascular diseases (CVDs) is increasing. It has become the leading cause of human mortality. As a natural drug, borneol (BO) not only has anti-inflammatory, anti-oxidant, anti-apoptotic, anti-coagulant activities and improves energy metabolism but can also promote drugs to enter the target organs or tissues through various physiological barriers, such as the blood-brain barrier (BBB), mucous membrane, skin. Thus, it has a significant therapeutic effect on various CVDs, which has been confirmed in a large number of studies. However, the pharmacological actions and mechanisms of BO on CVDs have not been fully investigated. Hence, this review summarizes the pharmacological actions and possible mechanisms of BO, which provides novel ideas for the treatment of CVDs.
Palabras clave
(+)-borneol (PubChem CID: 6552009); (+)-isoborneol (PubChem CID: 6973640); (-)-borneol (PubChem CID: 1201518); (−)-isoborneol (PubChem CID: 6321405); Borneol; Cardio-cerebrovascular diseases; Mechanisms; Pharmacological actions; Therapeutics; borneol (PubChem CID: 64685); isoborneol (PubChem CID: 6973640)
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Canfanos
/
Cardiotónicos
/
Enfermedades Cardiovasculares
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Pharmacol Res
Asunto de la revista:
FARMACOLOGIA
Año:
2021
Tipo del documento:
Article