An in vitro pharmacodynamic spiking study of befovacimab, a tissue factor pathway inhibitor monoclonal antibody, in blood samples from patients with severe FVIII deficiency.

Martin, Erika J; Nolte, Melinda E; Kuhn, Janice; Schmidt, Nicole; Pfaff, Nils; Brophy, Donald F

Martin, Erika J; Nolte, Melinda E; Kuhn, Janice; Schmidt, Nicole; Pfaff, Nils; Brophy, Donald F.

Afiliación

Martin EJ; Coagulation Advancement Laboratory, Department of Pharmacotherapy & Outcomes Sciences, Virginia Commonwealth University (VCU) School of Pharmacy, Richmond, VA, USA.
Nolte ME; Department of Internal Medicine, Division of Hematology/Oncology, VCU School of Medicine, Richmond, VA, USA.
Kuhn J; Department of Internal Medicine, Division of Hematology/Oncology, VCU School of Medicine, Richmond, VA, USA.
Schmidt N; Research & Development, Pharmaceuticals, Bayer AG, Berlin, Germany.
Pfaff N; Research & Development, Pharmaceuticals, Bayer AG, Wuppertal, Germany.
Brophy DF; Coagulation Advancement Laboratory, Department of Pharmacotherapy & Outcomes Sciences, Virginia Commonwealth University (VCU) School of Pharmacy, Richmond, VA, USA.

Haemophilia ; 27(4): 690-698, 2021 Jul.

Article en En | MEDLINE | ID: mdl-33915599

Asunto(s)

Anticuerpos Monoclonales; Hemofilia A; Anticuerpos Monoclonales/farmacología; Factor VIII; Hemofilia A/tratamiento farmacológico; Humanos; Lipoproteínas; Trombina

Palabras clave

coagulation; haemophilia; thrombin generation assay; tissue factor pathway inhibitor; whole blood clotting

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hemofilia A / Anticuerpos Monoclonales Límite: Humans Idioma: En Revista: Haemophilia Asunto de la revista: HEMATOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos

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