Rational Design of a Highly Selective Near-Infrared Two-Photon Fluorogenic Probe for Imaging Orthotopic Hepatocellular Carcinoma Chemotherapy.
Angew Chem Int Ed Engl
; 60(28): 15418-15425, 2021 07 05.
Article
en En
| MEDLINE
| ID: mdl-33942436
ABSTRACT
Selective fluorescence imaging of biomarkers inâ
vivo and inâ
situ for evaluating orthotopic hepatocellular carcinoma (HCC) chemotherapy remains a great challenge due to current imaging agents suffering from the potential interferences of other hydrolases. Herein, we observed that carbamate unit showed a high selectivity toward the HCC-related biomarker carboxylesterase (CE) for evaluation of treatment. A near-infrared two-photon fluorescent probe was developed to not only specially image CE activity inâ
vivo and inâ
situ but also target orthotopic liver tumor after systemic administration. The inâ
vivo signals of the probe correlate well with tumor apoptosis, making it possible to evaluate the status of treatment. The probe enables the imaging of CE activity inâ
situ with a high-resolution three-dimensional view for the first time. This study may promote advances in optical imaging approaches for precise imaging-guided diagnosis of HCC inâ
situ and its evaluation of treatment.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Fotones
/
Carcinoma Hepatocelular
/
Imagen Óptica
/
Colorantes Fluorescentes
/
Antineoplásicos
Límite:
Humans
Idioma:
En
Revista:
Angew Chem Int Ed Engl
Año:
2021
Tipo del documento:
Article