An infection-induced RhoB-Beclin 1-Hsp90 complex enhances clearance of uropathogenic Escherichia coli.

Miao, Chunhui; Yu, Mingyu; Pei, Geng; Ma, Zhenyi; Zhang, Lisong; Yang, Jianming; Lv, Junqiang; Zhang, Zhi-Song; Keller, Evan T; Yao, Zhi; Wang, Quan

Miao, Chunhui; Yu, Mingyu; Pei, Geng; Ma, Zhenyi; Zhang, Lisong; Yang, Jianming; Lv, Junqiang; Zhang, Zhi-Song; Keller, Evan T; Yao, Zhi; Wang, Quan.

Afiliación

Miao C; Department of Immunology, Key Laboratory of Immune Microenvironment and Disease of the Educational Ministry of China, Tianjin Key Laboratory of Cellular and Molecular Immunology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China.
Yu M; Department of Immunology, Key Laboratory of Immune Microenvironment and Disease of the Educational Ministry of China, Tianjin Key Laboratory of Cellular and Molecular Immunology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China.
Pei G; Department of Immunology, Key Laboratory of Immune Microenvironment and Disease of the Educational Ministry of China, Tianjin Key Laboratory of Cellular and Molecular Immunology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China.
Ma Z; Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Tianjin Key Laboratory of Medical Epigenetics, Tianjin Medical University, Tianjin, China.
Zhang L; State Key Laboratory of Medicinal Chemical Biology and College of Pharmacy, Collaborative Innovation Center for Biotherapy, Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin, China.
Yang J; Department of Immunology, Key Laboratory of Immune Microenvironment and Disease of the Educational Ministry of China, Tianjin Key Laboratory of Cellular and Molecular Immunology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China.
Lv J; Department of Immunology, Key Laboratory of Immune Microenvironment and Disease of the Educational Ministry of China, Tianjin Key Laboratory of Cellular and Molecular Immunology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China.
Zhang ZS; State Key Laboratory of Medicinal Chemical Biology and College of Pharmacy, Collaborative Innovation Center for Biotherapy, Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin, China.
Keller ET; Department of Urology, University of Michigan, Ann Arbor, MI, USA.
Yao Z; Department of Immunology, Key Laboratory of Immune Microenvironment and Disease of the Educational Ministry of China, Tianjin Key Laboratory of Cellular and Molecular Immunology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China. yaozhi@tmu.edu.cn.
Wang Q; 2011 Collaborative Innovation Center of Tianjin for Medical Epigenetics, Tianjin Medical University, Tianjin, China. yaozhi@tmu.edu.cn.

Nat Commun ; 12(1): 2587, 2021 05 10.

Article en En | MEDLINE | ID: mdl-33972537

Asunto(s)

Autofagosomas/metabolismo; Beclina-1/metabolismo; Infecciones por Escherichia coli/metabolismo; Proteínas HSP90 de Choque Térmico/metabolismo; Infecciones Urinarias/metabolismo; Escherichia coli Uropatógena/crecimiento & desarrollo; Proteína de Unión al GTP rhoB/metabolismo; Animales; Autofagosomas/genética; Autofagosomas/ultraestructura; Beclina-1/genética; Línea Celular; Epitelio/metabolismo; Epitelio/microbiología; Infecciones por Escherichia coli/genética; Infecciones por Escherichia coli/microbiología; Femenino; Técnicas de Silenciamiento del Gen; Proteínas HSP90 de Choque Térmico/genética; Humanos; Ratones; Ratones Endogámicos C57BL; Ratones Noqueados; Microscopía Electrónica de Transmisión; Proteínas Asociadas a Microtúbulos/metabolismo; Unión Proteica; Estabilidad Proteica; ARN Interferente Pequeño; Proteínas Recombinantes; Vejiga Urinaria/metabolismo; Vejiga Urinaria/microbiología; Infecciones Urinarias/genética; Infecciones Urinarias/microbiología; Escherichia coli Uropatógena/patogenicidad; Proteína de Unión al GTP rhoB/genética

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 2_ODS3 / 3_ND Problema de salud: 2_enfermedades_transmissibles / 3_neglected_diseases / 3_zoonosis Asunto principal: Infecciones Urinarias / Proteínas HSP90 de Choque Térmico / Proteína de Unión al GTP rhoB / Infecciones por Escherichia coli / Escherichia coli Uropatógena / Autofagosomas / Beclina-1 Límite: Animals / Female / Humans Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2021 Tipo del documento: Article País de afiliación: China

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google