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Lycopene and Caffeic Acid Phenethyl Ester Affect Caspase-3 Activity, but Do Not Alter the NO Pathway in Lung Tissue Damage Induced by Cisplatin.
Rancic, Milan; Ristic, Lidija; Rancic, Andrija; Krtinic, Dane; Ilic, Bojan; Pavlovic, Milorad; Milojkovic, Milos; Zivkovic, Nikola; Sokolovic, Dusan.
Afiliación
  • Rancic M; Department for internal medicine, Faculty of Medicine, University of Nis, Nis, Serbia.
  • Ristic L; Clinic for lung diseases, Clinical center Nis, Nis, Serbia.
  • Rancic A; Department for internal medicine, Faculty of Medicine, University of Nis, Nis, Serbia.
  • Krtinic D; Clinic for lung diseases, Clinical center Nis, Nis, Serbia.
  • Ilic B; Faculty of Medicine, University of Nis, Nis, Serbia.
  • Pavlovic M; Department for pharmacology with toxicology, Faculty of Medicine, University of Nis, Nis, Serbia.
  • Milojkovic M; Clinic for oncology, Clinical center Nis, Nis, Serbia.
  • Zivkovic N; Clinic for thoracic surgery, Clinical center Nis, Nis, Serbia.
  • Sokolovic D; Clinic for thoracic surgery, Clinical center Nis, Nis, Serbia.
Pharmacology ; 106(7-8): 400-408, 2021.
Article en En | MEDLINE | ID: mdl-33975324
ABSTRACT

INTRODUCTION:

Antioxidants such as lycopene (LCP) and caffeic acid phenethyl ester (CAPE) represent ideal molecules for the treatment of different reactive oxygen species (ROS) associated disorders. Cisplatin is a chemotherapeutic agent, causing an increase in ROS and DNA damage, with numerous side effects, which include lung toxicity. In the presents study, we evaluated and mutually compared the potential of LCP and CAPE in preventing cisplatin-induced rat lung damage.

METHODS:

The study was done using pathohistological analysis and a panel of biochemical parameters that reflect lung oxidative tissue damage, inflammation, and apoptosis.

RESULTS:

The obtained results suggest that cisplatin (10 mg/kg) causes significant disturbances in the lung tissue morphology, followed by an increase in lipid peroxidization and protein modification. Also, a pronounced inflammatory response and cell apoptosis cascade activation was noted. Both LCP and CAPE were able to mitigate the changes, to a different extent, in oxidative damage and apoptosis progression induced by cisplatin. However, they both had limited effect on inflammation since they only prevented an increase in myeloperoxidase activity but had not been able to prevent the NO generation.

CONCLUSION:

It is hard to be exact in saying whether LCP or CAPE is better in preventing cis-platin-induced lung damage since they obviously possess different mechanisms of action.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Alcohol Feniletílico / Ácidos Cafeicos / Cisplatino / Licopeno Límite: Animals Idioma: En Revista: Pharmacology Año: 2021 Tipo del documento: Article

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Alcohol Feniletílico / Ácidos Cafeicos / Cisplatino / Licopeno Límite: Animals Idioma: En Revista: Pharmacology Año: 2021 Tipo del documento: Article
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