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A SARS-CoV-2 neutralizing antibody with extensive Spike binding coverage and modified for optimal therapeutic outcomes.
Guo, Yu; Huang, Lisu; Zhang, Guangshun; Yao, Yanfeng; Zhou, He; Shen, Shu; Shen, Bingqing; Li, Bo; Li, Xin; Zhang, Qian; Chen, Mingjie; Chen, Da; Wu, Jia; Fu, Dan; Zeng, Xinxin; Feng, Mingfang; Pi, Chunjiang; Wang, Yuan; Zhou, Xingdong; Lu, Minmin; Li, Yarong; Fang, Yaohui; Lu, Yun-Yueh; Hu, Xue; Wang, Shanshan; Zhang, Wanju; Gao, Ge; Adrian, Francisco; Wang, Qisheng; Yu, Feng; Peng, Yun; Gabibov, Alexander G; Min, Juan; Wang, Yuhui; Huang, Heyu; Stepanov, Alexey; Zhang, Wei; Cai, Yan; Liu, Junwei; Yuan, Zhiming; Zhang, Chen; Lou, Zhiyong; Deng, Fei; Zhang, Hongkai; Shan, Chao; Schweizer, Liang; Sun, Kun; Rao, Zihe.
Afiliación
  • Guo Y; State Key Laboratory of Medicinal Chemical Biology and College of Pharmacy, Nankai University, Tianjin, People's Republic of China. guoyu@nankai.edu.cn.
  • Huang L; Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.
  • Zhang G; State Key Laboratory of Medicinal Chemical Biology and College of Pharmacy, Nankai University, Tianjin, People's Republic of China.
  • Yao Y; College of Life Science, Nankai University, Tianjin, People's Republic of China.
  • Zhou H; Center for Biosafety Mega-Science, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, Hubei, People's Republic of China.
  • Shen S; HiFiBio (Hong Kong) Limited, Central, Hong Kong.
  • Shen B; State Key Laboratory of Virology and National Virus Resource Center, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, Hubei, People's Republic of China.
  • Li B; HiFiBio (Hong Kong) Limited, Central, Hong Kong.
  • Li X; State Key Laboratory of Medicinal Chemical Biology and College of Pharmacy, Nankai University, Tianjin, People's Republic of China.
  • Zhang Q; College of Life Science, Nankai University, Tianjin, People's Republic of China.
  • Chen M; State Key Laboratory of Medicinal Chemical Biology and College of Pharmacy, Nankai University, Tianjin, People's Republic of China.
  • Chen D; College of Life Science, Nankai University, Tianjin, People's Republic of China.
  • Wu J; HiFiBio (Hong Kong) Limited, Central, Hong Kong.
  • Fu D; HiFiBio (Hong Kong) Limited, Central, Hong Kong.
  • Zeng X; State Key Laboratory of Medicinal Chemical Biology and College of Pharmacy, Nankai University, Tianjin, People's Republic of China.
  • Feng M; College of Life Science, Nankai University, Tianjin, People's Republic of China.
  • Pi C; HiFiBio (Hong Kong) Limited, Central, Hong Kong.
  • Wang Y; State Key Laboratory of Medicinal Chemical Biology and College of Pharmacy, Nankai University, Tianjin, People's Republic of China.
  • Zhou X; Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.
  • Lu M; HiFiBio (Hong Kong) Limited, Central, Hong Kong.
  • Li Y; HiFiBio (Hong Kong) Limited, Central, Hong Kong.
  • Fang Y; State Key Laboratory of Medicinal Chemical Biology and College of Pharmacy, Nankai University, Tianjin, People's Republic of China.
  • Lu YY; College of Life Science, Nankai University, Tianjin, People's Republic of China.
  • Hu X; State Key Laboratory of Medicinal Chemical Biology and College of Pharmacy, Nankai University, Tianjin, People's Republic of China.
  • Wang S; College of Life Science, Nankai University, Tianjin, People's Republic of China.
  • Zhang W; HiFiBio (Hong Kong) Limited, Central, Hong Kong.
  • Gao G; Wuxi Biologics Limited, Shanghai, People's Republic of China.
  • Adrian F; State Key Laboratory of Virology and National Virus Resource Center, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, Hubei, People's Republic of China.
  • Wang Q; HiFiBio (Hong Kong) Limited, Central, Hong Kong.
  • Yu F; State Key Laboratory of Virology and National Virus Resource Center, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, Hubei, People's Republic of China.
  • Peng Y; HiFiBio (Hong Kong) Limited, Central, Hong Kong.
  • Gabibov AG; Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.
  • Min J; Center for Biosafety Mega-Science, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, Hubei, People's Republic of China.
  • Wang Y; HiFiBio (Hong Kong) Limited, Central, Hong Kong.
  • Huang H; Shanghai Synchrotron Radiation Facility, Shanghai Advanced Research Institute, Chinese Academy of Sciences, Shanghai, People's Republic of China.
  • Stepanov A; Shanghai Synchrotron Radiation Facility, Shanghai Advanced Research Institute, Chinese Academy of Sciences, Shanghai, People's Republic of China.
  • Zhang W; Center for Biosafety Mega-Science, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, Hubei, People's Republic of China.
  • Cai Y; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.
  • Liu J; Center for Biosafety Mega-Science, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, Hubei, People's Republic of China.
  • Yuan Z; State Key Laboratory of Medicinal Chemical Biology and College of Pharmacy, Nankai University, Tianjin, People's Republic of China.
  • Zhang C; College of Life Science, Nankai University, Tianjin, People's Republic of China.
  • Lou Z; Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.
  • Deng F; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.
  • Zhang H; State Key Laboratory of Medicinal Chemical Biology and College of Pharmacy, Nankai University, Tianjin, People's Republic of China.
  • Shan C; College of Life Science, Nankai University, Tianjin, People's Republic of China.
  • Schweizer L; Tianjin International Joint Academy of Biotechnology & Medicine, Tianjin, People's Republic of China.
  • Sun K; Tianjin International Joint Academy of Biotechnology & Medicine, Tianjin, People's Republic of China.
  • Rao Z; Center for Biosafety Mega-Science, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, Hubei, People's Republic of China.
Nat Commun ; 12(1): 2623, 2021 05 11.
Article en En | MEDLINE | ID: mdl-33976198
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 4_TD Problema de salud: 4_pneumonia Asunto principal: Anticuerpos Neutralizantes / Glicoproteína de la Espiga del Coronavirus / SARS-CoV-2 / COVID-19 / Anticuerpos Monoclonales / Anticuerpos Antivirales Límite: Animals / Female / Humans / Male Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2021 Tipo del documento: Article
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 4_TD Problema de salud: 4_pneumonia Asunto principal: Anticuerpos Neutralizantes / Glicoproteína de la Espiga del Coronavirus / SARS-CoV-2 / COVID-19 / Anticuerpos Monoclonales / Anticuerpos Antivirales Límite: Animals / Female / Humans / Male Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2021 Tipo del documento: Article