No strong HLA association with MOG antibody disease in the UK population.
Ann Clin Transl Neurol
; 8(7): 1502-1507, 2021 07.
Article
en En
| MEDLINE
| ID: mdl-33991459
ABSTRACT
Improvements in assays for detecting serum antibodies against myelin oligodendrocyte glycoprotein (MOG) have led to the appreciation of MOG-antibody-associated disease (MOGAD) as a novel disorder. However, much remains unknown about its etiology. We performed human leukocyte antigen (HLA) analysis in 82 MOGAD patients of European ancestry in the UK population. No HLA class II associations were observed, thus questioning the mechanism of anti-MOG antibody generation. A weak protective association of HLA-C*0304 was observed (OR = 0.26, 95% CI = 0.10-0.71, pc = 0.013), suggesting a need for continued efforts to better understand MOGAD genetics and pathophysiology.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Autoanticuerpos
/
Neuromielitis Óptica
/
Estudios de Asociación Genética
/
Glicoproteína Mielina-Oligodendrócito
/
Antígenos HLA
Tipo de estudio:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
País/Región como asunto:
Europa
Idioma:
En
Revista:
Ann Clin Transl Neurol
Año:
2021
Tipo del documento:
Article
País de afiliación:
Reino Unido