The complex role of SIRT7 in p53 stabilization: nucleophosmin joins the debate.
Mol Cell Oncol
; 8(3): 1896349, 2021 Mar 31.
Article
en En
| MEDLINE
| ID: mdl-34027038
ABSTRACT
Release of nucleophosmin (NPM) from nucleoli following stress promotes rapid stabilization of the tumor suppressor p53 (TP53, best known as p53). Nucleoplasmic NPM binds to the ubiquitin ligase mouse double minute 2 (MDM2) and prevents MDM2-dependent p53 degradation. We recently demonstrated that sirtuin 7 (SIRT7) activates this pathway by directly deacetylating NPM following ultraviolet irradiation, indicating tumor-suppressive functions of SIRT7.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
Mol Cell Oncol
Año:
2021
Tipo del documento:
Article
País de afiliación:
Alemania