The Host Cellular Immune Response to Infection by Campylobacter Spp. and Its Role in Disease.
Infect Immun
; 89(8): e0011621, 2021 07 15.
Article
en En
| MEDLINE
| ID: mdl-34031129
ABSTRACT
Campylobacter spp. are the leading cause of bacterium-derived gastroenteritis worldwide, impacting 96 million individuals annually. Unlike other bacterial pathogens of the gastrointestinal tract, Campylobacter spp. lack many of the classical virulence factors that are often associated with the ability to induce disease in humans, including an array of canonical secretion systems and toxins. Consequently, the clinical manifestations of human campylobacteriosis and its resulting gastrointestinal pathology are believed to be primarily due to the host immune response toward the bacterium. Further, while gastrointestinal infection is usually self-limiting, numerous postinfectious disorders can occur, including the development of Guillain-Barré syndrome, reactive arthritis, and irritable bowel syndrome. Because gastrointestinal disease likely results from the host immune response, the development of these postinfectious disorders may be due to dysregulation or misdirection of the same inflammatory response. As a result, it is becoming increasingly important to the Campylobacter field, and human health, that the cellular immune responses toward Campylobacter be better understood, including which immunological events are critical to the development of disease and the postinfectious disorders mentioned above. In this review, we collectively cover the cellular immune responses across susceptible hosts to Campylobacter jejuni infection, along with the tissue pathology and postinfectious disorders which may develop.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Contexto en salud:
3_ND
Problema de salud:
3_diarrhea
Asunto principal:
Campylobacter
/
Infecciones por Campylobacter
/
Susceptibilidad a Enfermedades
/
Interacciones Huésped-Patógeno
/
Inmunidad Celular
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Infect Immun
Año:
2021
Tipo del documento:
Article
País de afiliación:
Estados Unidos