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α-[Amino(4-aminophenyl)thio]methylene-2-(trifluoromethyl)benzeneacetonitrile; Configurational equilibria in solution.
McElhinny, Charles J; Lewin, Anita H; Brieaddy, Larry; Fix, Scott; Imler, Gregory H; Deschamps, Jeffrey; Mascarella, S Wayne; Seltzman, Herbert H; Anantha Reddy, P; Carroll, F Ivy.
Afiliación
  • McElhinny CJ; Research Triangle Institute, P.O. Box 12194, Research Triangle Park, NC 27709, United States.
  • Lewin AH; Research Triangle Institute, P.O. Box 12194, Research Triangle Park, NC 27709, United States.
  • Brieaddy L; Research Triangle Institute, P.O. Box 12194, Research Triangle Park, NC 27709, United States.
  • Fix S; Research Triangle Institute, P.O. Box 12194, Research Triangle Park, NC 27709, United States.
  • Imler GH; United States Naval Research Laboratory (NRL), Laboratory for Biosensors and Biomaterials, Center for Biomolecular Science and Engineering, Washington, DC 20375, United States.
  • Deschamps J; United States Naval Research Laboratory (NRL), Laboratory for Biosensors and Biomaterials, Center for Biomolecular Science and Engineering, Washington, DC 20375, United States.
  • Mascarella SW; Research Triangle Institute, P.O. Box 12194, Research Triangle Park, NC 27709, United States.
  • Seltzman HH; Research Triangle Institute, P.O. Box 12194, Research Triangle Park, NC 27709, United States.
  • Anantha Reddy P; Research Triangle Institute, P.O. Box 12194, Research Triangle Park, NC 27709, United States.
  • Carroll FI; Research Triangle Institute, P.O. Box 12194, Research Triangle Park, NC 27709, United States.
Bioorg Chem ; 113: 104955, 2021 08.
Article en En | MEDLINE | ID: mdl-34034134
ABSTRACT
Inconsistent results have been reported for the effects of the mitogen-activating extracellular kinase (MEK) inhibitor α-[amino(4-aminophenyl)thio]methylene-2-(trifluoromethyl)benzeneacetonitrile (SL 327) on ethanol-induced conditioned place preference (EtOH-CPP). Since such inconsistencies may be due to the configurational composition of administered SL 327, the interconvertibility of the geometric isomers of this class of compounds has been investigated. This study provides conditions for determination of configurational composition of this class of compounds by HPLC and by 1H NMR and reports details of configurational equilibria as a function of medium and time in solution along with solubility data for SL 327 in aqueous DMSO. The results suggest that the apparently inconsistent results reported for CPP-EtOH may be due to the administration of suspension vs. solutions, as well as to different configurational compositions of SL 327.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Aminoacetonitrilo Idioma: En Revista: Bioorg Chem Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Aminoacetonitrilo Idioma: En Revista: Bioorg Chem Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos