Lead exposure and its association with neurological damage: systematic review and meta-analysis.
Environ Sci Pollut Res Int
; 28(28): 37001-37015, 2021 Jul.
Article
en En
| MEDLINE
| ID: mdl-34046839
ABSTRACT
Lead (Pb) is one of the most toxic and abundant elements in the earth's crust, which is pointed out that the intoxication caused by it may damage biological systems. This systematic review with meta-analysis aimed to evaluate the association between Pb exposure and neurological damage. This work was executed according to PRISMA guidelines, and seven online databases were consulted. Based on the PECO strategy, studies presenting humans as participants (populations) exposed to Pb (exposure) compared to non-exposed to Pb (control) evaluating the neurological impairment (outcome) were included. The quality and risk of bias were verified by Fowkes and Fulton checklist. Two meta-analyses were conducted considering Digit Symbol and Profile Mood tests. The certainty of the evidence was evaluated with the GRADE tool. This review identified 2019 studies, of which 12 were eligible according to the inclusion criteria. Eight were considered with a low risk of bias. All the studies elected showed that exposure to Pb is associated with neurological damage, but the meta-analysis did not show any difference for the evaluated tests, and the certainty of the evidence was considered very low. Nevertheless, the included studies showed that Pb occupational exposure is associated with neurological damage, and the main parameters evaluated for possible neurological damage were related to mnemonic aspects, reaction time, intelligence, attention disorders, and mood changes. Thus, our results revealed that a definitive demonstration of an association of Pb and neurological changes in humans is still a pending issue. Future studies should take into consideration more confident methods to answer this question.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Exposición Profesional
/
Plomo
Tipo de estudio:
Prognostic_studies
/
Risk_factors_studies
/
Systematic_reviews
Límite:
Humans
Idioma:
En
Revista:
Environ Sci Pollut Res Int
Asunto de la revista:
SAUDE AMBIENTAL
/
TOXICOLOGIA
Año:
2021
Tipo del documento:
Article
País de afiliación:
Brasil