Identification of a Pyrrole Intermediate Which Undergoes C-Glycosidation and Autoxidation to Yield the Final Product in Showdomycin Biosynthesis.

Ren, Daan; Kim, Minje; Wang, Shao-An; Liu, Hung-Wen

Ren, Daan; Kim, Minje; Wang, Shao-An; Liu, Hung-Wen.

Afiliación

Ren D; Department of Chemistry, Division of Chemical Biology and Medicinal Chemistry, College of Pharmacy, University of Texas at Austin, Austin, TX, 78712, USA.
Kim M; Department of Chemistry, Division of Chemical Biology and Medicinal Chemistry, College of Pharmacy, University of Texas at Austin, Austin, TX, 78712, USA.
Wang SA; Department of Chemistry, Division of Chemical Biology and Medicinal Chemistry, College of Pharmacy, University of Texas at Austin, Austin, TX, 78712, USA.
Liu HW; Department of Chemistry, Division of Chemical Biology and Medicinal Chemistry, College of Pharmacy, University of Texas at Austin, Austin, TX, 78712, USA.

Angew Chem Int Ed Engl ; 60(31): 17148-17154, 2021 07 26.

Article en En | MEDLINE | ID: mdl-34048627

Asunto(s)

Glicósidos/metabolismo; Péptido Sintasas/metabolismo; Pirroles/metabolismo; Showdomicina/biosíntesis; Glicósidos/química; Conformación Molecular; Oxidación-Reducción; Péptido Sintasas/química; Pirroles/química; Showdomicina/química

Palabras clave

C-glycosidation; C-nucleoside; autoxidation; biosynthesis; maleimide

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Péptido Sintasas / Pirroles / Showdomicina / Glicósidos Tipo de estudio: Diagnostic_studies Idioma: En Revista: Angew Chem Int Ed Engl Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos

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