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A GalNAc/Gal-specific lectin modulates immune responses via toll-like receptor 4 independently of carbohydrate-binding ability.
Chen, Shin-Tai; Liao, Jiahn-Haur; Huang, Kai-Fa; Lee, I-Ming; Wong, Wei-Ting; Wu, Shih-Hsiung; Hua, Kuo-Feng.
Afiliación
  • Chen ST; Department of Biotechnology and Animal Science, National Ilan University, Ilan 260, Taiwan. kuofenghua@gmail.com.
  • Liao JH; Institute of Biological Chemistry, Academia Sinica, Taipei 115, Taiwan. shwu@gate.sinica.edu.tw.
  • Huang KF; Institute of Biological Chemistry, Academia Sinica, Taipei 115, Taiwan. shwu@gate.sinica.edu.tw.
  • Lee IM; Institute of Biological Chemistry, Academia Sinica, Taipei 115, Taiwan. shwu@gate.sinica.edu.tw.
  • Wong WT; Department of Biotechnology and Animal Science, National Ilan University, Ilan 260, Taiwan. kuofenghua@gmail.com.
  • Wu SH; Institute of Biological Chemistry, Academia Sinica, Taipei 115, Taiwan. shwu@gate.sinica.edu.tw.
  • Hua KF; Department of Biotechnology and Animal Science, National Ilan University, Ilan 260, Taiwan. kuofenghua@gmail.com and Department of Medical Research, China Medical University Hospital, China Medical University, Taichung, Taiwan.
Chem Commun (Camb) ; 57(50): 6209-6212, 2021 Jun 22.
Article en En | MEDLINE | ID: mdl-34059855
ABSTRACT
Toll-like receptor 4 (TLR4) recognizes various protein ligands; however, the protein-TLR4 binding model is unclear. Here we demonstrate a Crenomytilus grayanus lectin (CGL)-TLR4/MD2 model to show that CGL interacts with a TLR4/myeloid differentiation factor 2 (MD2) complex independently of sugar-binding properties. CGL could suppress lipopolysaccharide-induced immune responses significantly, suggesting that TLR4 itself has potential as a therapeutic target.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carbohidratos / Antígeno 96 de los Linfocitos / Receptor Toll-Like 4 / Lectinas Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Chem Commun (Camb) Asunto de la revista: QUIMICA Año: 2021 Tipo del documento: Article País de afiliación: Taiwán
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carbohidratos / Antígeno 96 de los Linfocitos / Receptor Toll-Like 4 / Lectinas Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Chem Commun (Camb) Asunto de la revista: QUIMICA Año: 2021 Tipo del documento: Article País de afiliación: Taiwán