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Deletion of Lats1/2 in adult kidney epithelia leads to renal cell carcinoma.
Carter, Phoebe; Schnell, Ulrike; Chaney, Christopher; Tong, Betty; Pan, Xinchao; Ye, Jianhua; Mernaugh, Glenda; Cotton, Jennifer L; Margulis, Vitaly; Mao, Junhao; Zent, Roy; Evers, Bret M; Kapur, Payal; Carroll, Thomas J.
Afiliación
  • Carter P; Department of Molecular Biology and Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
  • Schnell U; Department of Molecular Biology and Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
  • Chaney C; Department of Molecular Biology and Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
  • Tong B; Department of Molecular Biology and Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
  • Pan X; Department of Molecular Biology and Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
  • Ye J; Department of Molecular Biology and Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
  • Mernaugh G; Department of Medicine, Division of Nephrology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
  • Cotton JL; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
  • Margulis V; Department of Urology.
  • Mao J; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
  • Zent R; Department of Medicine, Division of Nephrology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
  • Evers BM; Department of Pathology, and.
  • Kapur P; Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.Renal cell carcinoma (RCC) is the most common kidney cancer in humans. Misregulation of the Hippo/Warts pathway is frequently reported in RCC, suggesting a role in disease formation/progression. Paradoxi
  • Carroll TJ; Department of Urology.
J Clin Invest ; 131(11)2021 06 01.
Article en En | MEDLINE | ID: mdl-34060480
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carcinoma de Células Renales / Proteínas Serina-Treonina Quinasas / Eliminación de Gen / Proteínas Supresoras de Tumor / Riñón / Neoplasias Renales Límite: Animals / Humans Idioma: En Revista: J Clin Invest Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carcinoma de Células Renales / Proteínas Serina-Treonina Quinasas / Eliminación de Gen / Proteínas Supresoras de Tumor / Riñón / Neoplasias Renales Límite: Animals / Humans Idioma: En Revista: J Clin Invest Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos