Corneal Toxicity of Intravitreal Methotrexate Used for the Treatment of Proliferative Vitreoretinopathy in Silicone Oil-Filled Eyes: A Case Series.
Cornea
; 41(4): 499-501, 2022 Apr 01.
Article
en En
| MEDLINE
| ID: mdl-34074890
ABSTRACT
PURPOSE:
The purpose of this study was to evaluate the corneal toxicity of intravitreal methotrexate used for the prevention of proliferative vitreoretinopathy (PVR).METHODS:
In this retrospective case series, eyes with recurrent retinal detachment secondary to PVR were treated with intravitreal injections of 400 µg methotrexate at an average frequency of every 7 days after vitrectomy with silicone oil tamponade. Corneas were examined for corneal epitheliopathy by slit-lamp biomicroscopy before each injection.RESULTS:
Thirteen eyes of 12 patients were reviewed. All had a history of recurrent retinal detachment secondary to PVR treated with vitrectomy and silicone oil. The median age was 35 years (range 9-83). Four patients (33%) were female. The median follow-up duration was 8 weeks (range 5-10). The median BCVA (logMAR notation) was 2.00 preoperatively, 2.00 at 1 month postoperatively, and 2.00 at the most recent follow-up (P = 0.969). Ten eyes (77%) were pseudophakic. Nine eyes (69%) had a preexisting ocular comorbidity. The median number of injections was 8 (range 5-10). The median interval time between each injection was 7.0 days (range 5.8-10.5), and the median follow-up period beyond last injection was 16 weeks (range 8-28). Two eyes (15.4%) developed mild corneal epitheliopathy during the course of the treatment.CONCLUSIONS:
Most eyes in this small series tolerated methotrexate injections without corneal toxicity. In eyes that developed epitheliopathy, the findings were mild and not treatment-limiting.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Aceites de Silicona
/
Metotrexato
/
Vitreorretinopatía Proliferativa
/
Epitelio Corneal
/
Enfermedades de la Córnea
/
Endotaponamiento
/
Inmunosupresores
Tipo de estudio:
Diagnostic_studies
/
Observational_studies
Límite:
Adolescent
/
Adult
/
Aged
/
Aged80
/
Child
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Cornea
Año:
2022
Tipo del documento:
Article