Role of beta-adrenergic receptor subtypes in pig uterus contractility with inflammation.
Sci Rep
; 11(1): 11512, 2021 06 01.
Article
en En
| MEDLINE
| ID: mdl-34075189
ABSTRACT
Uterine inflammation is a very common and serious condition in domestic animals. To development and progression of this pathology often lead disturbances in myometrial contractility. Participation of ß1-, ß2- and ß3-adrenergic receptors (ARs) in noradrenaline (NA)-influenced contractility of the pig inflamed uterus was studied. The gilts of SAL- and E.coli-treated groups were administered saline or E.coli suspension into the uterine horns, respectively. Laparotomy was only done in the CON group. Compared to the period before NA administration, this neurotransmitter reduced the tension, amplitude and frequency in uterine strips of the CON and SAL groups. In the E.coli group, NA decreased the amplitude and frequency, and these parameters were lower than in other groups. In the CON, SAL and E.coli groups, ß1- and ß3-ARs antagonists in more cases did not significantly change and partly eliminated NA inhibitory effect on amplitude and frequency, as compared to NA action alone. In turn, ß2-ARs antagonist completely abolished NA relaxatory effect on these parameters in three groups. Summarizing, NA decreases the contractile amplitude and frequency of pig inflamed uterus via all ß-ARs subtypes, however, ß2-ARs have the greatest importance. Given this, pharmacological modulation of particular ß-ARs subtypes can be used to increase inflamed uterus contractility.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Contexto en salud:
2_ODS3
/
3_ND
Problema de salud:
2_enfermedades_transmissibles
/
3_neglected_diseases
/
3_zoonosis
Asunto principal:
Contracción Uterina
/
Receptores Adrenérgicos beta
/
Endometriosis
/
Endometrio
/
Escherichia coli
/
Infecciones por Escherichia coli
Límite:
Animals
Idioma:
En
Revista:
Sci Rep
Año:
2021
Tipo del documento:
Article
País de afiliación:
Polonia