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Management of urinary tract infections and antibiotic susceptibility patterns of bacterial isolates.
Amawi, Haneen A; U'wais, Hamza Tayseer; Nusair, Mohammad B; Al-Okour, Radwan; Amawi, Sadam; Al-Shatnawi, Samah; Abdi, Abdikarim.
Afiliación
  • Amawi HA; Department of Clinical Pharmacy and Pharmacy Practice, College of Pharmacy, Yarmouk University, Irbid, Jordan.
  • U'wais HT; Department of Clinical Pharmacy, Faculty of Pharmacy, Near East University, Nicosia, Cyprus.
  • Nusair MB; Department of Clinical Pharmacy and Pharmacy Practice, College of Pharmacy, Yarmouk University, Irbid, Jordan.
  • Al-Okour R; Department of Urology and General Surgery, Faculty of Medicine, King Abdullah University Hospital, Jordan University of Science and Technology, Irbid, Jordan.
  • Amawi S; Department of Urology and General Surgery, Faculty of Medicine, King Abdullah University Hospital, Jordan University of Science and Technology, Irbid, Jordan.
  • Al-Shatnawi S; Department of Clinical Pharmacy, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid, Jordan.
  • Abdi A; Department of Clinical Pharmacy, Faculty of Pharmacy, Near East University, Nicosia, Cyprus.
Int J Clin Pract ; 75(10): e14475, 2021 Oct.
Article en En | MEDLINE | ID: mdl-34107556
AIM OF STUDY: Urinary tract infections (UTIs) are among the most common infections affecting individuals of different ages worldwide. Antimicrobial agents are usually the first-line treatment for UTIs, and the use of the prescribed antibiotic is escalating, resulting in increased rates of bacterial resistance and UTI recurrence. The current study aimed to identify the causative bacteria in Jordan, to explore their resistance pattern to antibiotics and to describe drug-related problems (DRPs) associated with UTI management. METHODS: This prospective, descriptive study was conducted in two major health institutions in two cities in Jordan over a period of six months. The study population included inpatients and outpatients diagnosed with UTIs. Patients' data were collected directly from patients using data collection sheet and from patients' charts. RESULTS: A total of 273 patients were included, of whom 56.4% were women. Urine cultures were obtained from 81% of the patients. Escherichia coli was the most common causative pathogen (50.6%), followed by Klebsiella pneumonia (10.8%). Extended spectrum beta-lactamase (ESBL) producing E. coli was the most commonly detected organism across all types of UTIs. Ceftriaxone and imipenem/cilastatin were most commonly administered to hospitalised patients, whilst ciprofloxacin and co-triamzaxole were the most commonly prescribed in outpatient clinics. The susceptibility results for parenteral antibiotics showed high rates of resistance to cefazolin and ticarcillin. Additionally, high rates of resistance to fluoroquinolones were identified. Further, several DRPs were identified. High rates of resistance to commonly prescribed antibiotics were detected. DRPs (ie, inappropriate antibiotic dosage, unnecessary antibiotic prescribing, inappropriate duration of therapy and prescribing of ineffective antibiotics) were relatively common. CONCLUSION: The present study highlights the need for clinical pharmacists to manage the high level of drug related problems by providing updated information about proper drug selection, rational drug use and patient education and counselling.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 3_ND Problema de salud: 3_neglected_diseases / 3_zoonosis Asunto principal: Infecciones Urinarias / Infecciones por Escherichia coli Tipo de estudio: Observational_studies Límite: Female / Humans Idioma: En Revista: Int J Clin Pract Asunto de la revista: MEDICINA Año: 2021 Tipo del documento: Article País de afiliación: Jordania

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 3_ND Problema de salud: 3_neglected_diseases / 3_zoonosis Asunto principal: Infecciones Urinarias / Infecciones por Escherichia coli Tipo de estudio: Observational_studies Límite: Female / Humans Idioma: En Revista: Int J Clin Pract Asunto de la revista: MEDICINA Año: 2021 Tipo del documento: Article País de afiliación: Jordania
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