Tea tree oil extract causes mitochondrial superoxide production and apoptosis as an anticancer agent, promoting tumor infiltrating neutrophils cytotoxic for breast cancer to induce tumor regression.

Clark, Amanda M; Magawa, Chandi; Pliego-Zamora, Adriana; Low, Pauline; Reynolds, Max; Ralph, Stephen J

Clark, Amanda M; Magawa, Chandi; Pliego-Zamora, Adriana; Low, Pauline; Reynolds, Max; Ralph, Stephen J.

Afiliación

Clark AM; School of Pharmacy and Medical Science, Menzies Health Institute of Queensland, Griffith University, Gold Coast Campus, Southport, Queensland 4222, Australia.
Magawa C; School of Pharmacy and Medical Science, Menzies Health Institute of Queensland, Griffith University, Gold Coast Campus, Southport, Queensland 4222, Australia.
Pliego-Zamora A; School of Pharmacy and Medical Science, Menzies Health Institute of Queensland, Griffith University, Gold Coast Campus, Southport, Queensland 4222, Australia.
Low P; School of Pharmacy and Medical Science, Menzies Health Institute of Queensland, Griffith University, Gold Coast Campus, Southport, Queensland 4222, Australia.
Reynolds M; School of Pharmacy and Medical Science, Menzies Health Institute of Queensland, Griffith University, Gold Coast Campus, Southport, Queensland 4222, Australia; Australian Botanical Bioscience Pty. Ltd., Australia.
Ralph SJ; School of Pharmacy and Medical Science, Menzies Health Institute of Queensland, Griffith University, Gold Coast Campus, Southport, Queensland 4222, Australia. Electronic address: s.ralph@griffith.edu.au.

Biomed Pharmacother ; 140: 111790, 2021 Aug.

Article en En | MEDLINE | ID: mdl-34119930

Asunto(s)

Antineoplásicos/uso terapéutico; Neoplasias Mamarias Experimentales/tratamiento farmacológico; Melaleuca; Aceite de Árbol de Té/uso terapéutico; Animales; Antineoplásicos/farmacología; Apoptosis/efectos de los fármacos; Ciclo Celular/efectos de los fármacos; Línea Celular Tumoral; Chlorocebus aethiops; Femenino; Humanos; Neoplasias Mamarias Experimentales/inmunología; Neoplasias Mamarias Experimentales/metabolismo; Neoplasias Mamarias Experimentales/patología; Ratones Transgénicos; Mitocondrias/efectos de los fármacos; Mitocondrias/metabolismo; Neutrófilos/efectos de los fármacos; Neutrófilos/inmunología; Extractos Vegetales; Especies Reactivas de Oxígeno/metabolismo; Superóxidos/metabolismo; Aceite de Árbol de Té/farmacología; Células Vero

Palabras clave

Apoptosis; Breast cancer; Cytotoxicity; Melaleuca alternifolia concentrate; Tumor infiltrating neutrophils

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Aceite de Árbol de Té / Melaleuca / Neoplasias Mamarias Experimentales / Antineoplásicos Tipo de estudio: Etiology_studies Límite: Animals / Female / Humans Idioma: En Revista: Biomed Pharmacother Año: 2021 Tipo del documento: Article País de afiliación: Australia

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