A Comparative Review of the Cell Biology, Biochemistry, and Genetics of Lactose Synthesis.
J Mammary Gland Biol Neoplasia
; 26(2): 181-196, 2021 06.
Article
en En
| MEDLINE
| ID: mdl-34125364
ABSTRACT
Lactose is the primary carbohydrate in the milk of most mammals and is unique in that it is only synthesized by epithelial cells in the mammary glands. Lactose is also essential for the development and nutrition of infants. Across species, the concentration of lactose in milk holds a strong positive correlation with overall milk volume. Additionally, there is a range of examples where the onset of lactose synthesis as well as the content of lactose in milk varies between species and throughout a lactation. Despite this diversity, the precursors, genes, proteins and ions that regulate lactose synthesis have not received the depth of study they likely deserve relative to the significance of this simple and abundant molecule. Through this review, our objective is to highlight the requirements for lactose synthesis at the biochemical, cellular and temporal levels through a comparative approach. This overview also serves as the prelude to a companion review describing the dietary, hormonal, molecular, and genetic factors that regulate lactose synthesis.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Lactancia
/
Glándulas Mamarias Humanas
/
Lactosa
/
Glándulas Mamarias Animales
Límite:
Animals
/
Female
/
Humans
Idioma:
En
Revista:
J Mammary Gland Biol Neoplasia
Asunto de la revista:
NEOPLASIAS
Año:
2021
Tipo del documento:
Article
País de afiliación:
Estados Unidos