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Automatic detection of synaptic partners in a whole-brain Drosophila electron microscopy data set.
Buhmann, Julia; Sheridan, Arlo; Malin-Mayor, Caroline; Schlegel, Philipp; Gerhard, Stephan; Kazimiers, Tom; Krause, Renate; Nguyen, Tri M; Heinrich, Larissa; Lee, Wei-Chung Allen; Wilson, Rachel; Saalfeld, Stephan; Jefferis, Gregory S X E; Bock, Davi D; Turaga, Srinivas C; Cook, Matthew; Funke, Jan.
Afiliación
  • Buhmann J; HHMI Janelia Research Campus, Ashburn, VA, USA.
  • Sheridan A; Institute of Neuroinformatics, University of Zurich and ETH Zurich, Zurich, Switzerland.
  • Malin-Mayor C; HHMI Janelia Research Campus, Ashburn, VA, USA.
  • Schlegel P; HHMI Janelia Research Campus, Ashburn, VA, USA.
  • Gerhard S; MRC Laboratory of Molecular Biology, Cambridge, UK.
  • Kazimiers T; Harvard Medical School, Boston, MA, USA.
  • Krause R; UniDesign Solutions GmbH, Zürich, Switzerland.
  • Nguyen TM; HHMI Janelia Research Campus, Ashburn, VA, USA.
  • Heinrich L; HHMI Janelia Research Campus, Ashburn, VA, USA.
  • Lee WA; Institute of Neuroinformatics, University of Zurich and ETH Zurich, Zurich, Switzerland.
  • Wilson R; Harvard Medical School, Boston, MA, USA.
  • Saalfeld S; HHMI Janelia Research Campus, Ashburn, VA, USA.
  • Jefferis GSXE; F.M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA, USA.
  • Bock DD; Harvard Medical School, Boston, MA, USA.
  • Turaga SC; HHMI Janelia Research Campus, Ashburn, VA, USA.
  • Cook M; MRC Laboratory of Molecular Biology, Cambridge, UK.
  • Funke J; University of Vermont, Burlington, VA, USA.
Nat Methods ; 18(7): 771-774, 2021 07.
Article en En | MEDLINE | ID: mdl-34168373
ABSTRACT
We develop an automatic method for synaptic partner identification in insect brains and use it to predict synaptic partners in a whole-brain electron microscopy dataset of the fruit fly. The predictions can be used to infer a connectivity graph with high accuracy, thus allowing fast identification of neural pathways. To facilitate circuit reconstruction using our results, we develop CIRCUITMAP, a user interface add-on for the circuit annotation tool CATMAID.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sinapsis / Procesamiento de Imagen Asistido por Computador / Encéfalo Tipo de estudio: Diagnostic_studies Límite: Animals Idioma: En Revista: Nat Methods Asunto de la revista: TECNICAS E PROCEDIMENTOS DE LABORATORIO Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Añadir a Mi BVS
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sinapsis / Procesamiento de Imagen Asistido por Computador / Encéfalo Tipo de estudio: Diagnostic_studies Límite: Animals Idioma: En Revista: Nat Methods Asunto de la revista: TECNICAS E PROCEDIMENTOS DE LABORATORIO Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos