Mutagenesis of OA-6129 carbapenem-producing blocked mutants and the biosynthesis of carbapenems.
J Antibiot (Tokyo)
; 41(7): 899-907, 1988 Jul.
Article
en En
| MEDLINE
| ID: mdl-3417564
ABSTRACT
Streptomyces fulvoviridis A933 17M9 1501 is an A933 acylase-defective mutant derived from S. fulvoviridis A933 17M9 and thus produces the OA-6129 group of carbapenems and carbapenams. By further mutation of mutant 1501, 4 types of mutants (OA-6129 A + B1 + B2 producers; OA-6129 A + B2 producers; an OA-6129 A producer; non-producers) were obtained. The second type of mutant strains 4N 3607, 5NA 3949-40 and 5NE 252 proved useful for the fermentative production of carbapenem OA-6129 B2. These results of mutagenesis demonstrated that the sequence of carbapenem bioconversion in the horizontal route was hydroxylation at C-8----isomerization at C-6----sulfation at C-8 hydroxyl.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Streptomyces
/
Tienamicinas
Idioma:
En
Revista:
J Antibiot (Tokyo)
Año:
1988
Tipo del documento:
Article
País de afiliación:
Japón