Pathological and immunohistochemical aspects of acute megakaryoblastic leukaemia in a cat - Short communication.
Acta Vet Hung
; 69(2): 175-179, 2021 07 02.
Article
en En
| MEDLINE
| ID: mdl-34224399
ABSTRACT
An adult, mixed-breed, feline leukaemia virus (FeLV-) positive female cat was presented with mucosal jaundice and a history of anorexia and constipation for three days. Physical examination revealed splenomegaly, cachexia, and dehydration. Humane euthanasia was conducted, followed by postmortem examination. Grossly, the cat was icteric, and presented hepatomegaly with multifocal white spots and splenomegaly. Histologically, the bone marrow was nearly completely replaced by a proliferation of megakaryocytes and megakaryoblasts, and there was a proliferation of fibrous connective tissue. Similar neoplastic proliferation was observed infiltrating the liver, lymph nodes, spleen, kidney, skeletal muscle, and lungs. Immunohistochemistry was performed for von Willebrand Factor (VWF), CD79α, CD3, feline immunodeficiency virus, FeLV, and CD61. Marked cytoplasmic labelling was observed in the neoplastic cells for FeLV, VWF and CD61, corroborating the diagnosis of acute megakaryoblastic leukaemia.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Enfermedades de los Gatos
/
Leucemia Megacarioblástica Aguda
Tipo de estudio:
Diagnostic_studies
Límite:
Animals
Idioma:
En
Revista:
Acta Vet Hung
Año:
2021
Tipo del documento:
Article
País de afiliación:
Brasil