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Pathological and immunohistochemical aspects of acute megakaryoblastic leukaemia in a cat - Short communication.
Molossi, Franciéli Adriane; Henker, Luan Cleber; Cecco, Bianca Santana De; Bandinelli, Marcele Bettim; Rodrigues, Rochana; Sonne, Luciana; Driemeier, David; Pavarini, Saulo Petinatti.
Afiliación
  • Molossi FA; 1Department of Veterinary Pathology, Federal University of Rio Grande do Sul (UFRGS), Av. Bento Gonçalves 9090, Porto Alegre, Rio Grande do Sul, 91540-000, Brazil.
  • Henker LC; 1Department of Veterinary Pathology, Federal University of Rio Grande do Sul (UFRGS), Av. Bento Gonçalves 9090, Porto Alegre, Rio Grande do Sul, 91540-000, Brazil.
  • Cecco BS; 1Department of Veterinary Pathology, Federal University of Rio Grande do Sul (UFRGS), Av. Bento Gonçalves 9090, Porto Alegre, Rio Grande do Sul, 91540-000, Brazil.
  • Bandinelli MB; 1Department of Veterinary Pathology, Federal University of Rio Grande do Sul (UFRGS), Av. Bento Gonçalves 9090, Porto Alegre, Rio Grande do Sul, 91540-000, Brazil.
  • Rodrigues R; 2Chatterie Centro de Saúde do Gato, Private Veterinary Clinic, Porto Alegre, Rio Grande do Sul, Brazil.
  • Sonne L; 1Department of Veterinary Pathology, Federal University of Rio Grande do Sul (UFRGS), Av. Bento Gonçalves 9090, Porto Alegre, Rio Grande do Sul, 91540-000, Brazil.
  • Driemeier D; 1Department of Veterinary Pathology, Federal University of Rio Grande do Sul (UFRGS), Av. Bento Gonçalves 9090, Porto Alegre, Rio Grande do Sul, 91540-000, Brazil.
  • Pavarini SP; 1Department of Veterinary Pathology, Federal University of Rio Grande do Sul (UFRGS), Av. Bento Gonçalves 9090, Porto Alegre, Rio Grande do Sul, 91540-000, Brazil.
Acta Vet Hung ; 69(2): 175-179, 2021 07 02.
Article en En | MEDLINE | ID: mdl-34224399
ABSTRACT
An adult, mixed-breed, feline leukaemia virus (FeLV-) positive female cat was presented with mucosal jaundice and a history of anorexia and constipation for three days. Physical examination revealed splenomegaly, cachexia, and dehydration. Humane euthanasia was conducted, followed by postmortem examination. Grossly, the cat was icteric, and presented hepatomegaly with multifocal white spots and splenomegaly. Histologically, the bone marrow was nearly completely replaced by a proliferation of megakaryocytes and megakaryoblasts, and there was a proliferation of fibrous connective tissue. Similar neoplastic proliferation was observed infiltrating the liver, lymph nodes, spleen, kidney, skeletal muscle, and lungs. Immunohistochemistry was performed for von Willebrand Factor (VWF), CD79α, CD3, feline immunodeficiency virus, FeLV, and CD61. Marked cytoplasmic labelling was observed in the neoplastic cells for FeLV, VWF and CD61, corroborating the diagnosis of acute megakaryoblastic leukaemia.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades de los Gatos / Leucemia Megacarioblástica Aguda Tipo de estudio: Diagnostic_studies Límite: Animals Idioma: En Revista: Acta Vet Hung Año: 2021 Tipo del documento: Article País de afiliación: Brasil

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades de los Gatos / Leucemia Megacarioblástica Aguda Tipo de estudio: Diagnostic_studies Límite: Animals Idioma: En Revista: Acta Vet Hung Año: 2021 Tipo del documento: Article País de afiliación: Brasil
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