A single homogeneous assay for simultaneous measurement of bispecific antibody target binding.

Christian, Elizabeth A; Hussmann, G Patrick; Babu, Meghna; Prophet, Meagan; Mazor, Yariv; Chen, Weimin; Grigoriadou, Christina; Lin, Shihua

Christian, Elizabeth A; Hussmann, G Patrick; Babu, Meghna; Prophet, Meagan; Mazor, Yariv; Chen, Weimin; Grigoriadou, Christina; Lin, Shihua.

Afiliación

Christian EA; Department of Analytical Sciences, BioPharmaceuticals Development, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, USA. Electronic address: elizabeth.christian@astrazeneca.com.
Hussmann GP; Department of Analytical Sciences, BioPharmaceuticals Development, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, USA.
Babu M; Department of Analytical Sciences, BioPharmaceuticals Development, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, USA.
Prophet M; Department of Analytical Sciences, BioPharmaceuticals Development, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, USA.
Mazor Y; Department of Antibody Discovery and Protein Engineering, BioPharmaceuticals Development, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, USA.
Chen W; Department of Analytical Sciences, BioPharmaceuticals Development, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, USA.
Grigoriadou C; Department of Analytical Sciences, BioPharmaceuticals Development, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, USA.
Lin S; Department of Analytical Sciences, BioPharmaceuticals Development, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, USA.

J Immunol Methods ; 496: 113099, 2021 09.

Article en En | MEDLINE | ID: mdl-34224737

Asunto(s)

Anticuerpos Biespecíficos/inmunología; Especificidad de Anticuerpos; Antígenos/inmunología; Antígeno CTLA-4/inmunología; Inmunoensayo; Receptor de Muerte Celular Programada 1/inmunología; Anticuerpos Biespecíficos/metabolismo; Complejo Antígeno-Anticuerpo; Antígenos/metabolismo; Sitios de Unión de Anticuerpos; Tampones (Química); Antígeno CTLA-4/metabolismo; Ensayo de Inmunoadsorción Enzimática; Epítopos; Humanos; Concentración de Iones de Hidrógeno; Cinética; Valor Predictivo de las Pruebas; Receptor de Muerte Celular Programada 1/metabolismo; Unión Proteica; Reproducibilidad de los Resultados

Palabras clave

AlphaLISA; AlphaPlex; Antigen binding; Bispecific antibodies; Immunoassay

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Inmunoensayo / Anticuerpos Biespecíficos / Antígeno CTLA-4 / Receptor de Muerte Celular Programada 1 / Especificidad de Anticuerpos / Antígenos Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: J Immunol Methods Año: 2021 Tipo del documento: Article

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