One-Step Synthesis of Triphenylphosphonium Salts from (Het)arylmethyl Alcohols.
J Org Chem
; 86(14): 9838-9846, 2021 07 16.
Article
en En
| MEDLINE
| ID: mdl-34232646
ABSTRACT
Two approaches for the synthesis of substituted phosphonium salts from easily available benzyl alcohols and their heterocyclic analogs have been developed. The developed protocols are complementary the direct mixing of alcohol, trimethylsilyl bromide, and triphenylphosphine in 1,4-dioxane followed by heating at 80 °C was found to be more efficient for acid-sensitive substrates, such as salicyl or furfuryl alcohols as well as secondary benzyl alcohols, while a one-pot procedure including sequential addition of trimethylsilyl bromide and triphenylphosphine gave higher yields for benzyl alcohols bearing electroneutral or electron-withdrawing substituents.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Sales (Química)
/
Alcoholes
Idioma:
En
Revista:
J Org Chem
Año:
2021
Tipo del documento:
Article