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Brigatinib causes tumor shrinkage in both NF2-deficient meningioma and schwannoma through inhibition of multiple tyrosine kinases but not ALK.
Chang, Long-Sheng; Oblinger, Janet L; Smith, Abbi E; Ferrer, Marc; Angus, Steven P; Hawley, Eric; Petrilli, Alejandra M; Beauchamp, Roberta L; Riecken, Lars Björn; Erdin, Serkan; Poi, Ming; Huang, Jie; Bessler, Waylan K; Zhang, Xiaohu; Guha, Rajarshi; Thomas, Craig; Burns, Sarah S; Gilbert, Thomas S K; Jiang, Li; Li, Xiaohong; Lu, Qingbo; Yuan, Jin; He, Yongzheng; Dixon, Shelley A H; Masters, Andrea; Jones, David R; Yates, Charles W; Haggarty, Stephen J; La Rosa, Salvatore; Welling, D Bradley; Stemmer-Rachamimov, Anat O; Plotkin, Scott R; Gusella, James F; Guinney, Justin; Morrison, Helen; Ramesh, Vijaya; Fernandez-Valle, Cristina; Johnson, Gary L; Blakeley, Jaishri O; Clapp, D Wade.
Afiliación
  • Chang LS; The Research Institute at Nationwide Children's Hospital and Department of Pediatrics, Center for Childhood Cancer and Blood Diseases, The Ohio State University College of Medicine, Columbus, Ohio, United States of America.
  • Oblinger JL; The Research Institute at Nationwide Children's Hospital and Department of Pediatrics, Center for Childhood Cancer and Blood Diseases, The Ohio State University College of Medicine, Columbus, Ohio, United States of America.
  • Smith AE; Department of Pediatrics, Indiana University, School of Medicine, Indianapolis, Indiana, United States of America.
  • Ferrer M; Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland, United States of America.
  • Angus SP; Department of Pediatrics, Indiana University, School of Medicine, Indianapolis, Indiana, United States of America.
  • Hawley E; University of North Carolina School of Medicine, Chapel Hill, North Carolina, United States of America.
  • Petrilli AM; Department of Pediatrics, Indiana University, School of Medicine, Indianapolis, Indiana, United States of America.
  • Beauchamp RL; Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Lake Nona-Orlando, Florida, United States of America.
  • Riecken LB; Massachusetts General Hospital and Department of Neurology, Center for Genomic Medicine, Harvard Medical School, Boston, Massachusetts, United States of America.
  • Erdin S; Leibniz Institute on Aging-Fritz-Lipmann Institute (FLI), Jena, Germany.
  • Poi M; Massachusetts General Hospital and Department of Neurology, Center for Genomic Medicine, Harvard Medical School, Boston, Massachusetts, United States of America.
  • Huang J; Division of Pharmacy Practice and Science, The Ohio State University College of Pharmacy, Columbus, Ohio, United States of America.
  • Bessler WK; The Research Institute at Nationwide Children's Hospital and Department of Pediatrics, Center for Childhood Cancer and Blood Diseases, The Ohio State University College of Medicine, Columbus, Ohio, United States of America.
  • Zhang X; Department of Pediatrics, Indiana University, School of Medicine, Indianapolis, Indiana, United States of America.
  • Guha R; Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland, United States of America.
  • Thomas C; Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland, United States of America.
  • Burns SS; Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland, United States of America.
  • Gilbert TSK; The Research Institute at Nationwide Children's Hospital and Department of Pediatrics, Center for Childhood Cancer and Blood Diseases, The Ohio State University College of Medicine, Columbus, Ohio, United States of America.
  • Jiang L; University of North Carolina School of Medicine, Chapel Hill, North Carolina, United States of America.
  • Li X; Department of Pediatrics, Indiana University, School of Medicine, Indianapolis, Indiana, United States of America.
  • Lu Q; Department of Pediatrics, Indiana University, School of Medicine, Indianapolis, Indiana, United States of America.
  • Yuan J; Department of Pediatrics, Indiana University, School of Medicine, Indianapolis, Indiana, United States of America.
  • He Y; Department of Pediatrics, Indiana University, School of Medicine, Indianapolis, Indiana, United States of America.
  • Dixon SAH; Department of Pediatrics, Indiana University, School of Medicine, Indianapolis, Indiana, United States of America.
  • Masters A; Department of Pediatrics, Indiana University, School of Medicine, Indianapolis, Indiana, United States of America.
  • Jones DR; Department of Pediatrics, Indiana University, School of Medicine, Indianapolis, Indiana, United States of America.
  • Yates CW; Department of Pediatrics, Indiana University, School of Medicine, Indianapolis, Indiana, United States of America.
  • Haggarty SJ; Department of Otolaryngology and Head/Neck Surgery, Indiana University School of Medicine, Indianapolis, Indiana, United States of America.
  • La Rosa S; Massachusetts General Hospital and Department of Neurology, Center for Genomic Medicine, Harvard Medical School, Boston, Massachusetts, United States of America.
  • Welling DB; Children's Tumor Foundation, New York, New York, United States of America.
  • Stemmer-Rachamimov AO; Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Massachusetts General Hospital and Harvard University, Boston, Massachusetts, United States of America.
  • Plotkin SR; Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America.
  • Gusella JF; Massachusetts General Hospital and Department of Neurology, Center for Genomic Medicine, Harvard Medical School, Boston, Massachusetts, United States of America.
  • Guinney J; Center for Genomic Medicine, Massachusetts General Hospital and Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts, United States of America.
  • Morrison H; Sage Bionetworks, Seattle, Washington, United States of America.
  • Ramesh V; Leibniz Institute on Aging-Fritz-Lipmann Institute (FLI), Jena, Germany.
  • Fernandez-Valle C; Massachusetts General Hospital and Department of Neurology, Center for Genomic Medicine, Harvard Medical School, Boston, Massachusetts, United States of America.
  • Johnson GL; Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Lake Nona-Orlando, Florida, United States of America.
  • Blakeley JO; University of North Carolina School of Medicine, Chapel Hill, North Carolina, United States of America.
  • Clapp DW; Departments of Neurology, Neurosurgery and Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.
PLoS One ; 16(7): e0252048, 2021.
Article en En | MEDLINE | ID: mdl-34264955
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Compuestos Organofosforados / Pirimidinas / Proteínas Tirosina Quinasas / Neurofibromina 2 / Neoplasias Meníngeas / Meningioma / Neurilemoma Tipo de estudio: Etiology_studies Límite: Humans Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Añadir a Mi BVS
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XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Compuestos Organofosforados / Pirimidinas / Proteínas Tirosina Quinasas / Neurofibromina 2 / Neoplasias Meníngeas / Meningioma / Neurilemoma Tipo de estudio: Etiology_studies Límite: Humans Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos