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Immortalized striatal precursor neurons from Huntington's disease patient-derived iPS cells as a platform for target identification and screening for experimental therapeutics.
Akimov, Sergey S; Jiang, Mali; Kedaigle, Amanda J; Arbez, Nicolas; Marque, Leonard O; Eddings, Chelsy R; Ranum, Paul T; Whelan, Emma; Tang, Anthony; Wang, Ronald; DeVine, Lauren R; Talbot, Conover C; Cole, Robert N; Ratovitski, Tamara; Davidson, Beverly L; Fraenkel, Ernest; Ross, Christopher A.
Afiliación
  • Akimov SS; Division of Neurobiology, Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
  • Jiang M; Division of Neurobiology, Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
  • Kedaigle AJ; Department of Biological Engineering, Computational and Systems Biology Graduate Program, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.
  • Arbez N; Division of Neurobiology, Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
  • Marque LO; Division of Neurobiology, Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
  • Eddings CR; Division of Neurobiology, Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
  • Ranum PT; The Department of Pathology and Laboratory Medicine, The University of Pennsylvania, The Raymond G Perelman Center for Cellular and Molecular Therapeutics, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
  • Whelan E; Division of Neurobiology, Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
  • Tang A; Division of Neurobiology, Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
  • Wang R; Division of Neurobiology, Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
  • DeVine LR; Mass Spectrometry and Proteomics Facility, Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
  • Talbot CC; The Johns Hopkins School of Medicine, Institute for Basic Biomedical Sciences, Baltimore, MD 21205, USA.
  • Cole RN; Mass Spectrometry and Proteomics Facility, Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
  • Ratovitski T; Division of Neurobiology, Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
  • Davidson BL; The Department of Pathology and Laboratory Medicine, The University of Pennsylvania, The Raymond G Perelman Center for Cellular and Molecular Therapeutics, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
  • Fraenkel E; The Department of Pathology and Laboratory Medicine, The University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Ross CA; Department of Biological Engineering, Computational and Systems Biology Graduate Program, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.
Hum Mol Genet ; 30(24): 2469-2487, 2021 11 30.
Article en En | MEDLINE | ID: mdl-34296279
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 6_ODS3_enfermedades_notrasmisibles Problema de salud: 6_alzheimer_other_dementias / 6_mental_health_behavioral_disorders Asunto principal: Enfermedad de Huntington / Células Madre Pluripotentes Inducidas Tipo de estudio: Diagnostic_studies / Guideline / Prognostic_studies / Screening_studies Límite: Humans Idioma: En Revista: Hum Mol Genet Asunto de la revista: BIOLOGIA MOLECULAR / GENETICA MEDICA Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 6_ODS3_enfermedades_notrasmisibles Problema de salud: 6_alzheimer_other_dementias / 6_mental_health_behavioral_disorders Asunto principal: Enfermedad de Huntington / Células Madre Pluripotentes Inducidas Tipo de estudio: Diagnostic_studies / Guideline / Prognostic_studies / Screening_studies Límite: Humans Idioma: En Revista: Hum Mol Genet Asunto de la revista: BIOLOGIA MOLECULAR / GENETICA MEDICA Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos