Artificial nucleic acid backbones and their applications in therapeutics, synthetic biology and biotechnology.
Emerg Top Life Sci
; 5(5): 691-697, 2021 11 12.
Article
en En
| MEDLINE
| ID: mdl-34297063
ABSTRACT
The modification of DNA or RNA backbones is an emerging technology for therapeutic oligonucleotides, synthetic biology and biotechnology. Despite a plethora of reported artificial backbones, their vast potential is not fully utilised. Limited synthetic accessibility remains a major bottleneck for the wider application of backbone-modified oligonucleotides. Thus, a variety of readily accessible artificial backbones and robust methods for their introduction into oligonucleotides are urgently needed to utilise their full potential in therapeutics, synthetic biology and biotechnology.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Ácidos Nucleicos
Idioma:
En
Revista:
Emerg Top Life Sci
Año:
2021
Tipo del documento:
Article
País de afiliación:
Reino Unido