Valveless pumping behavior of the simulated embryonic heart tube as a function of contractile patterns and myocardial stiffness.
Biomech Model Mechanobiol
; 20(5): 2001-2012, 2021 Oct.
Article
en En
| MEDLINE
| ID: mdl-34297252
ABSTRACT
During development, the heart begins pumping as a valveless multilayered tube capable of driving blood flow throughout the embryonic vasculature. The mechanical properties and how they interface with pumping function are not well-defined at this stage. Here, we evaluate pumping patterns using a fluid-structure interaction computational model, combined with experimental data and an energetic analysis to investigate myocardial mechanical properties. Through this work, we propose that a myocardium modeled as a Neo-Hookean material with a material constant on the order of 10 kPa is necessary for the heart tube to function with an optimal pressure and cardiac output.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Pez Cebra
/
Corazón
/
Hemodinámica
/
Contracción Miocárdica
/
Miocardio
Límite:
Animals
Idioma:
En
Revista:
Biomech Model Mechanobiol
Asunto de la revista:
ENGENHARIA BIOMEDICA
Año:
2021
Tipo del documento:
Article
País de afiliación:
Estados Unidos