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Transplantation of Pluripotent Stem Cell-Derived Cardiomyocytes into a Myocardial Infarction Model of Cynomolgus Monkey.
Kobayashi, Hideki; Ichimura, Hajime; Ohashi, Noburou; Shiba, Yuji.
Afiliación
  • Kobayashi H; Department of Cardiovascular Medicine, Shinshu University School of Medicine, Nagano, Japan.
  • Ichimura H; Division of Cardiovascular Surgery, Department of Surgery, Shinshu University School of Medicine, Nagano, Japan.
  • Ohashi N; Division of Cardiovascular Surgery, Department of Surgery, Shinshu University School of Medicine, Nagano, Japan.
  • Shiba Y; Department of Regenerative Science and Medicine, Institute for Biomedical Sciences, Shinshu University, Nagano, Japan. yshiba@shinshu-u.ac.jp.
Methods Mol Biol ; 2320: 295-302, 2021.
Article en En | MEDLINE | ID: mdl-34302666
ABSTRACT
Recent evidence has provided exciting proof of concepts for the use of pluripotent stem cell-derived cardiomyocytes (PSC-CMs) for cardiac repair; however, large animal studies, which better reflect human disease, are required for clinical application. Here, we describe how to create myocardial infarction in cynomolgus monkey followed by transplantation of PSC-CMs. This method ensures the establishment of a myocardial infarction model and enables reliable PSC-CM transplantation.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 1_ASSA2030 Problema de salud: 1_doencas_nao_transmissiveis Asunto principal: Miocitos Cardíacos / Modelos Animales de Enfermedad / Células Madre Pluripotentes Inducidas / Macaca fascicularis / Infarto del Miocardio Límite: Animals Idioma: En Revista: Methods Mol Biol Asunto de la revista: BIOLOGIA MOLECULAR Año: 2021 Tipo del documento: Article País de afiliación: Japón
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 1_ASSA2030 Problema de salud: 1_doencas_nao_transmissiveis Asunto principal: Miocitos Cardíacos / Modelos Animales de Enfermedad / Células Madre Pluripotentes Inducidas / Macaca fascicularis / Infarto del Miocardio Límite: Animals Idioma: En Revista: Methods Mol Biol Asunto de la revista: BIOLOGIA MOLECULAR Año: 2021 Tipo del documento: Article País de afiliación: Japón