Tumour microenvironment 3D-modelling: simplicity to complexity and back again.
Trends Cancer
; 7(11): 1033-1046, 2021 11.
Article
en En
| MEDLINE
| ID: mdl-34312120
ABSTRACT
Tumours are surrounded by a host of noncancerous cells that fulfil both supportive and suppressive roles within the tumour microenvironment (TME). The drive to understand the biology behind each of these components has led to a rapid expansion in the number and use of 3D in vitro models, as researchers find ways to incorporate multiple cell types into physiomimetic configurations. The use and increasing complexity of these models does however demand many considerations. In this review we discuss approaches adopted to recapitulate complex tumour biology in tractable 3D models. We consider how these cell types can be sourced and combined and examine methods for the deconvolution of complex multicellular models into manageable and informative outputs.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Microambiente Tumoral
/
Neoplasias
Límite:
Humans
Idioma:
En
Revista:
Trends Cancer
Año:
2021
Tipo del documento:
Article
País de afiliación:
Reino Unido