Dysbiotic microbiota interactions in Crohn's disease.
Gut Microbes
; 13(1): 1949096, 2021.
Article
en En
| MEDLINE
| ID: mdl-34313550
ABSTRACT
Crohn's disease (CD) is a major form of inflammatory bowel disease characterized by transmural inflammation along the alimentary tract. Changes in the microbial composition and reduction in species diversity are recognized as pivotal hallmarks in disease dynamics, challenging the gut barrier function and shaping a pathological immune response in genetically influenced subjects. The purpose of this review is to delve into the modification of the gut microbiota cluster network during CD progression and to discuss how this shift compromises the gut barrier integrity, granting the translocation of microbes and their products. We then complete the scope of the review by retracing gut microbiota dysbiosis interactions with the main pathophysiologic factors of CD, starting from the host's genetic background to the immune inflammatory and fibrotic processes, providing a standpoint on the lifestyle/exogenous factors and the potential benefits of targeting a specific gut microbiota.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Contexto en salud:
3_ND
Problema de salud:
3_zoonosis
Asunto principal:
Enfermedad de Crohn
/
Traslocación Bacteriana
/
Disbiosis
/
Microbioma Gastrointestinal
Tipo de estudio:
Etiology_studies
Límite:
Humans
Idioma:
En
Revista:
Gut Microbes
Año:
2021
Tipo del documento:
Article
País de afiliación:
España