Slowly progressive interstitial lung disease preceding typical dermatomyositis symptoms in anti-melanoma differentiation-associated gene 5 antibody-positive clinically amyopathic dermatomyositis.
Respir Med Case Rep
; 34: 101491, 2021.
Article
en En
| MEDLINE
| ID: mdl-34381685
ABSTRACT
A 73-year-old woman who visited our hospital complaining of dry cough for three months was refractory to antimicrobial therapy. Chest computed tomography revealed subpleural consolidation. Specimens obtained from surgical lung biopsy revealed subpleural perilobular airspace organization and fibrosis. After the biopsy, mechanic's hand and Gottron's papules appeared, and anti-melanoma differentiation-associated gene 5 (MDA5) antibody was found to be positive. Subsequently, anti-MDA5 antibody measured in cryopreserved serum from her first admission proved to be positive. It is difficult to suspect the presence of anti-MDA-5 antibody in patients with interstitial lung disease without typical dermatomyositis symptoms or slow disease progression.
ANCA, cytoplasmic autoantibody; Anti-melanoma differentiation-associated gene 5; BAL, bronchoalveolar lavage; CADM, clinically amyopathic dermatomyositis; CMV, cytomegalovirus; CT, computed tomography; Clinically amyopathic dermatomyositis; DM, dermatomyositis; HRCT, high-resolution computed tomography; ILD, interstitial lung disease; IVCY, intravenous cyclophosphamide; Interstitial lung disease; KL-6, Krebs von den Lungen-6; MDA5, anti-melanoma differentiation-associated gene 5; PSL, prednisolone; PaO2, partial pressure of oxygen; RP-ILD, rapidly progressive interstitial lung disease; SLB, surgical lung biopsy; Slowly progressive; Surgical lung biopsy; TBLB, transbronchial lung biopsy
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1
Colección:
01-internacional
Base de datos:
MEDLINE
Tipo de estudio:
Diagnostic_studies
/
Risk_factors_studies
Idioma:
En
Revista:
Respir Med Case Rep
Año:
2021
Tipo del documento:
Article
País de afiliación:
Japón