Evidence of intergenerational transmission of diethylstilbestrol health effects: hindsight and insight.
Biol Reprod
; 105(3): 681-686, 2021 09 14.
Article
en En
| MEDLINE
| ID: mdl-34387644
ABSTRACT
This review summarizes key findings from the US National Cancer Institute (NCI) diethylstilbestrol (DES) Combined Cohort Study with a focus on the results of the NCI Third Generation Study, a cohort of DES-exposed and -unexposed granddaughters. Findings to date from the Third Generation Study are discussed in the context of other research efforts and case reports, suggesting an intergenerational heritability of DES-related effects. The DES story serves as a model for the influence of endocrine disrupting chemicals on human health. It also serves as a warning of the special hazards of pregnancy exposures, and more broadly, of the potential for invisible health consequences arising from new or changing exposures.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Efectos Tardíos de la Exposición Prenatal
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Exposición Materna
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Dietilestilbestrol
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Estrógenos no Esteroides
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Disruptores Endocrinos
Tipo de estudio:
Etiology_studies
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Incidence_studies
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Observational_studies
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Prevalence_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Female
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Humans
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Pregnancy
Idioma:
En
Revista:
Biol Reprod
Año:
2021
Tipo del documento:
Article
País de afiliación:
Estados Unidos